Description
Project KKULTR4, Subproject hj
Date In I tie ted i 2k March 1955
Date Expires* 1 Juno 1^62 ^
Fuais -current year* $20,7k0
\
PftiirFXR
Purpooc * Pharmacological and clinical testing ia ar.lcils and volunteers
of cheat cals and Moc^aicalsvhtch alter behavior. Provides consultation
on special problems of TSD Interest, j \
Status* Study completed on threshold doses of l$D-2$y.& oethed for
exploring antagonlsa of this drug by other agents, Voifc has been
initiated to evaluate comp ound producing azrnesla and having an alcohol
Jlke effect on behavior vlll be started. Evaluation of effects of
coablratloa of drugs of Interest to £SD is l/k coaplatef*.
5CT
o
H?" H
glate of Nfin 3Jfr5fij
BURh-AU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY-
C/O NEW JERSEY NEURO PSYCHIATRIC INSTITUTE *
BOX 1 0OO
PRINCETON. NEW JERSEY
HUMPHRY OSMOND. MRCS. LRCP. DPM
DmtcTC * \ March 25, 1984
Attached is our 1983-64 report/ and proposal for continued
research support by f or the coming year be-
ginning June 1, 1964. We hope that the report and the proposal
meet with the Board's approval so that you can advise us positively
when you visit us in the near future,
I shall be in Saturday and Sunday, May 2nd and
3rd. I can report in on Friday, May 1st in regard to a possible
conference if this is necessary.
Our financial report for the present grant year will be sent
shortly after June 1, 1964.
Yours sincerely,
CarlC. Pfeiffer, Ph.D., M.D.
Head, Section on Pharmacology
CCP:tt
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5 S&Ptemb er_1963.
Branch.
BB
Project Title —
Project Crypto
Branch Project No.
Contractor. — —
Category.
N. A.
mku ltra
- %
N. A.
behavioral activities support
Bell a v i oral Control Materials
,( VIa )
(formerly lib)
Item Classification— — —
Crypto Classificatio:
Project Engineer.
N. A.
Dr. C, C. Pfeif fer
Contract No._SsSa£fii5£t==42.
•ftp. of Contract JlKfflr™*.
Task No-
Date Initiated-
N. A.
March 1955
Cost.
_ $25- 000.00
Completion 1 1
Purpose: ror pliai .„ a cological and cl inicar test ing in animals and l,u,aa:
volunteers of drugs altering behavior.
Status: • Clinical testing programs involving evaluation of special-
ized materials are proceding according to plan.
Internally generated in TSD.
r ~
■ *
i
Requirement:
FINAL
Branch— 51 -
Project Title
D?|g 3 1 October 1963
BEHAVIORAL ACTIVITIES SUPPORT
Category, Behavior|l Control^atcri^ls (
(formerly I lb;
■ w a *
N.A, Item Classification — ^ — • -- — — “
:< VIa >
. MK ULTRA
Project Cryp t0 —
C„p to Classification — UnclassifASA-
A
Branch Project No.
Contractor-
N. A, Project Engineer
Dr. C. C. Pfeiffer
Contract No Subiir0.iect_J7 Task No—
« V
Type of Contract — MKULTRA _ Date Initiator
March 1955
_-$?5^000.00
Complet ion
■» . inical test itiE In animals and human
Purpose: For pharmacological and clinical iesi b
volunteers of drugs altering behavior.
Status: Sati
isfactorily terminated. Contract replaced LyMK ULTRA 144
•Reouireir.ent:
Internally generated in TSD.
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V BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY*
I Cyo NEW JERSEY NEURO-PSYCHIATRIC INSTITUTE
g ' BOX lOOO
L PRINCETON. NEW JERSEY
3
I have been informed that your granting committee has again
agreed to support our reseai'ch for a oner year period beginning
June 1, 1965 and extending until Kay 31, 1964. On behalf of the
New Jersey Mental Health Research & Development Fund, Inc. and my
co-workers we wish to thank you for this expressed confidence in
our originality and productivity.
Attached you will find a succinct summary of our expenditures
on the 1962-63 grant. Exact detailed expenditures are available in
the office of the Fund.
»
Best regards.
Yours sincerely,
Carl C. Pfeiffer, M.D.
_ Head, Section on Neu?opharmaeology
CCP:tt
" j’F.i ■/L 1 ™
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FINANCIAL Rl^gL
June 1, 1962 to May 31, 1963
ftnnunl Grant to ».J. Mental He'alrtRnsearoh ^volopjent Fund, Ino.
Res
jsearch Project of Carl C. Heiffer, Fb-D. , M.D.
Receipts
$25,000.00
Expenditures
Salaries
Vv’ages
Expt'l Subjects
Travel
Total
$19,635,54
3,546.49
878.00
939.97
$25,000.00
Carl C. Pfeiffer /pJVTdT, M.D.
W^V
■ » c.
Henry P. David, Ph.D.
Secretary-Treasurer
N.J. Mental Health Research
and Development Fund, Inc.
a
Date
»
Branchs ES-
21 F/Uv-ry
19';
Category — -
Behavior Control
-{ llh )
Project Title
Project Crypto—JS^^A
Branch Project No — ^-'A. - — -
Item Classification——
11. A.
Crypto Classification-
Unclassified
Project Engineer.
Contractor.
Dr. C. C. Pfeiffer „ —
Contract No.
Subprojec 1 # ^7
Task No—
N.A.
Type of Contract /rlTTRA
„ Date Initiated
Cost
$25,00 0. 00
Completion Date.
Continuing ( r enewed April 19 fe)
Purpose: F or pharmacological and clinical testing in animals and human voir: :v
of drugs altering t>eht\vior.
Status:
'-Clinical tenting programs involvin C evaluation of specialized,
ere -oroccding according to plan.
I
nterirls
?^;Z2£V£i7i SOURCE: Internally generated in TSD.
( \
Dale
C
rvw.t, ^.- w Dr. C.C. Pfeiffer, New Jersey Neuro -> Psychiatric Institute,
Princeton* New Jersey
Contract No_^ife3^keLiAl
Tyi>e of Contract h*.K ULTRA
$ 25,000
Purpose: For
Task No N. A, _ .
__ Date Initiated _ —
Completion Date Con tinu tngjre.^w'ed April *6r
Status: - V.ork scheduled for FT 62 has been completed and a satisfactory
final report has been submitted.
ft*
C.
V? - II
NEW JERSEY MENTAL HEALTH
RESEARCH AND DEVELOPMENT FUND, INC,
7*rus?£*«9
JOSEPH M. TOBIN, M. D., Chairman * PAUL HAUN, M. D, Vice Chairman * KENRY P. DAVID, PH. D, Sanitary Tteamitat
V. TF.RRELL DAVIS, M.D. • MAURICE O KOTT, Ph D, • DOUGLAS H. MacNEIL • LLOYD W. McCORKLE, Ph D,
I
June 1 , 1961
BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY
SECTION ON PHARMACOLOGY
c/o New Jersey Neuro-Psychiatric Institute
Princeton, New Jersey
A<$<freii C&xtMgspomJenc* to:
ttenxy 3P, Divsd, Ph D.
Secretary Tr«ft»urtf
S Jill Lent
TifeMon I, K. J.
RECEIPTS:
November 1 S6 1
February 1962
$ 15,370.00
15,370.00
Totai Receipts
$ 30,7^0.00
EXPENDITURES:
Salaries 6- Wages
Travel
Permanent Equipment
Consumable Supplies
All Other
$10,356.13
1,476.80
16,794.62
1 , 771.66
340.^9
Total Expenditures
$ 30,740.00
Henry P. David, Secretary-Treasurer
^ ff / / /
CarT, C. Pfeiffer, fh.O'V'H.D.
Principal Investigator*
Head, Section on pharmacology
Contribution! art Drdurclible lor Fadrial Incvn* Tar Furpoma.
S'SJt »
Jt '
G
t/ / 2,
**S3ES83biT‘
BIVOICJB
For Services
CKRriFlCATIOKS
/J
(l) It is hereby certified that this is I a v o I c e__.- ^ ^ apply ■- ’ -S vO
Sub-project Ro._ of_ satisfactory,
that services are"P V.ccceplic hed in accordance with cubital agree-
ments, that a detailed egecclv^f -the- -'payments and receipts is o-i file
in TSD/bBj that this bill is J ust and c orrect and that payment thereof
has not yet been issde.
Chief, TSD/bIoI osteal Branch
Eg v€ • _ — r • | * ** / -»
- iJ April — ■—• — .
(2) It is hereby certified that this Invoice applies to Subproject
of KKULT RA vhicli voo duly approved, and that the project
Is carried out in cccorcance vlth the t&uor&nduQ of 13 April
1953 froa the DC I to the DD/A, and the extension of this authority
in subsequent msEorsnda.v : ^
Chief, TSO
Date:
receipt
^ y/.
$
Receipt is acknowledged of Treasurer's Check No. 190924, dated
a
Receipt is also acknowledged of Treasurer's Check No. Y400026
dated May 3, 1962, drawn on the
in the amount of $1, 000.00, payable t
I
I
r'\
47-13
23 April 1962
MEMORANDUM FOR: Chief, Finance Division
VIA; \ TSP/Bud& et Officer
SUBJECT!
MKULTRA, Subproject 47, Invoice No, 1 3
Allotment No. 2125-1390-3902
1, Invoice No. 13 covering the above subproject in attached.
Payment should be made as follows
Cashier*# check In the amt^nt of $25, 000.00^
drawn on a
Cashier** check In/he amount of $1,000.00 drawn
>>***•..' ■ '
Chocks should be made payable to the H
in _ rj —
2, Please forward the checks to Chief, TSD/Blologlcal Branch
through TSD/Budget Officer by 1 5 May 1962.
3. This is a final Invoice. However, 'since - ' it is anticipated .
that additional funds will be obligated for this project, the files should
not be closed. 1 ^ coo. o<^
Y ^coo P-C — i t coo.ac*
& CHECK#— _ IN THE AMOUNT OK $. - - I _
RECEIVED. rt
| f riirriViifiT-f -*>B s aa*i — —
^^g^asgajgoa*^ CW.f.
mm
Attached:
Invoice At Certifications
Distribution!
Orig. & 2 - Addressee
1 - TSD/FASS
2 - TSD/BB
TSD/BB:J^ %
TSD/JOlologlcal Branch
24apr
"i*ia
1 CIRTiTT I :*.I r.^ Ci a.":
iitmts i». LLl ^ *
p-uci io / lie ’*v»r Ki ^ f ® ®
^ /cocc :T« •>: «c»
O'" * C
t
■ K'JSCRASSLlri FOR: Tho Cc^ptroner
/!K£5TIC»1J : Fierce £ivisi«a
•.»
SI-3J3CT : ^KUl^RA, Subproject
47
Usder the authority r raatcd la tfca iUKoraodua eated 13 April 1$?3
frcg tbs SCX to tbs W/A, feed the exleticion of this authority tn sub-
Ecqxvsnt. K-anorcistla, Subproject .<7 tea been apprc%«ed cad 000» C'O
cf tbe ever-sll Reject l&Ui/gfiA' folds' liave bo£e obligated to cover the'
rubpre js: t f s orrc jrcf cad chouAd be cb'r* 3 ‘-d to rest cir tor 2 I^h-j390p39_04
API-aOVSD FOR OBLia^ON:
0? ltfiim;
x vl-o: ax >jv x">; \ c t- xx —
Chid, TSD
Cirlsf ,
TSS/Bio'c-^icaX Brt.nch
S.L: irib.-.t icn:
OrifTlr-ui Ci k - Adcicssce
- TSD/FASS
1 - TSD/BB
t c, MM r.t OS /r; am
f,,ua 10 ' > ^aj a$i73 t ?e> - 37g &•-
AC"tC-irf *3 O tKH "*
SUBJECT: MKUBTRA Subproject 47
1. The purpose of.' thus subproject 47 is to provide funds to continue
a research program being carried out by Carl C. Pfeiffer, MO.
2. The nature of the investigations to be carried out under the
direction of Dr, Pfeiffer encompasses pharmacological and clinical testing
in animals and human volunteers of chemicals and biochemicals which alter
behavior. Certain phases of other problems of interest to TSD will be -
investigated.
3. Dr. Pfeiffer is located at the New Jersey Neuro-Psychiatric
Institute in the Bureau of Research in Neurology^ind^Psychiatry, Princeton,
S'
New Jersey.
4. The funds for this pr'ojecfwill be transferred using the
a cut-out.
5. The cost of this program for a period of one year beginning 1 June
1962 will not exceed $25, 000. 00.— To this sum must be added $1, 000.00
representing a 4% service charge to thf
making the total amount $26, 000.00. Charges should be
»
made against Allotment No. 2125-1390-3902.
6. The New Jersey Mental Health Research and Development Fund
Inc., who administer the grant have agreed to provide
~"NT!Al
75
to: - y-
Yy tuiZllv «p f 7475 I O * **~**VS*#M V
t3 t 8 L"'xJy J s~
byCim*™
HI - 1 S'
with a summary accounting on an annual basis of all monies received .rom
the**®®®*- They have also agreed to return any unexpended funds
to the s non as possible upon the close of the grant year.
7 . 'phe requirement for a six months’ informal accounting on the part
of the principal investigator is waived.
8. Title to any permanent equipment purchased by funds granted the
New Jersey Neuro-Psychiatric Institute shall be retained by the Institute in
lieu of high overhead rates.
9. In connection with travel under this project, it is agreed that the
Agency will accept the travel documentation and accounting which conform
with the practices of the New Jersey Mental Health Research and Development
Fund, Inc.
10. It is agreed that technical reports reflecting the progress of the
research program shall be submitted at mutually acceptable intervals.
11. Dr. Pfeiffer has signed the Memorandum of Agreement and holds a
TOP SECRET Agency Security Approval '' .V
Cyiet,
SD/Bidfogical Branch
APPROVED FOR
OBLIGATION OF FUNDS:
7- ft
Chiel
Date:
22 APR 1965?
Distribution: •.••i.r- - - * - /
Original only I'
Attachment: Proposal 8t Budget
c m
[cyir
RESEARCH PROJECT APPLICATION
Grant Period June 1, 1962 through May 31, 1963
PROPOSAL: The testing inonimals and humans of chemicals and biochena-
— ... cals wMch a i t ar behavior.
PLACE
Section on Pharmacology
Bureau of Research in Neurology and Psychiatry
New Jersey Neuro Psychiatric Institute
Box 1000
Princeton, New Jersey
PRINCIPAL INVESTIGATOR :
CO-PRINCIPA L INVESTIGATOR
Carl C . Pf ei f f er , Ph.D., M. D .
GRAFT ADMINISTRATOR: New Jersey Mental Health Research and Developme t
- — ~ Fund, Inc.
1 Jill Lane, Trenton 8, New Jersey
Henry P. David Ph; D .% Secretary-Treasurer
INTRODUCTI ON:
Our research efforts have received local attention and approbation
during the past year so that we now have excellenl^rapport with the staffs
of both the Institute and the *Bordentown -Reformatory . We now have 10
volunteers per week from the latter, and we have a Clinical Investigative
Unit which will house 80 schizophrenics (present census 45 patients).
Current Status of the Pharmacology Unit
The laboratory is still undergoing minor construction, but material
progress has been made in the past year. The section for animal screening
and conditioning is complete. The sections for animal neuropharmacology
and clinical pharmacology have been constructed and put into operation,
andan electronic workshop has been set up. All these units are actively
at work in human and animal experiments as outlined below. The facilities
-joiici:
o
■77TT
xr M '
•sismss^K^Bmssmsmm.
of the clinical unit — experimental ward- --are nearing completion* and
«
are already in partial use. Still in varying stages of construction are
the biochemical pharmacology and medicinal chemistry units.
Personnel : Since the last report, the section has been joined by Drs.
- ' " ' _ C-
as planned. It is anticipated that two to three
more investigators at the .doctoral level will be needed, probably one
*%
more clinical pharmacologist, a medicinal chemist, and a biochemical
pharmacologist. Two engineers have been employed for design and con-
struction of new equipment and six lab assistants are now fully trained
to their various jobs.
Human s ubjects : Liaison with UeLw ^Jersey-State Reformatory — Bordentown
has been excellent, and a full complement of volunteers from that insti-
tution has been freely available. This group may be a better group for
this Kind of research, since they may be closer to the normal population
than were the Atlanta prisoners, the latter being recidivists and older
than the Box n dentown' group. In addition, other human volunteers have
been recruited, including female subjects, so that the population of
«
"normal" subjects available is now much more nearly representative of
the population at large. In addition, it has been possible already to
begin explorations with the psychotic patients from the experimental
ward, and some interesting results are already forthcoming (see below).
Equipment: Since the last report, the section has obtained a stereo-
taxic apparatus, a Grass Model III EEG, and a Sanborn 2000 magnetic
tape Data Recorder. In addition, we have ‘constructed two new integrators
for quantitative EEG; these are modeled after the Drohocki Integrator’;
but due to some circuit changes are more linear’, and have the advantage
of using all USA -made parts, so that maintenance is simplified. Two
more integrators are under construction which will a bow simultaneous
f
X
3.
o
integration of four leads, one from each lobe of a hemicranium. Also
under construction is a quantitative spectral analyzer for use with the
tape recorder in analyzing scalp EEG of humans as well as electrical
measurements from implanted electrodes in cortex and deeper structures
in brains of animals. Data will be entered on punch cards and processed
by a digital computer. Target date for beginning calibration and stan-
dardization is June 1, 1962. These new approaches allow determination
with great accuracy of effects of various classes of compounds and the
interactions of such agents.
A Barber Colman gas chroma tograph has been installed and a technician
is being trained to operate it. This makes possible correlative studies
of changes in brain constituents, changes in behavioral state, and electro
physiological data. This method is far more sensitive than previous
techniques, and allows accurate measurements to be made from much smaller
brain fractions. A Beckman pH meter a nd micr obu rette have also been
obtained for study of cholinesterase activity, since it appears that
psychotomimetic effects frequently if not always involve atropine-like
drug action (Pfeiffer, C.C., et al. Neurology, 9: 249-250, 1959)
Recent and current projects : These new techniques, together with the
unique availability of human subjects both normal and abnormal, make
possible a wide range of investigations on any class of compounds with
action on the central nervous system. These can begin at the most basic
level and move progressively to a level of sophistication beyond that of
almost any other setting. Some idea of the directions currently being
taken are indicated in recent and current work. Enclosed are -reprints of
publications during the past year. The following are also accepted for
pubiication and. will appear in the next few months:
d-
- . v- .\: -ia’rwji’ ^vtab'Jir vsSv*/ .•*.■'
tX v
..srtWW*
and Pfeiffer, C.C. Use o f nor m al subjects
for testing drugs (Upjohn Conference), Clin. Pharmacol & Therap.
At the Federation meetings in
ft, this month.
will report on,*
-» C - , „
and and Pfeiffer will report on.
Qua ntitative electroencephalographi c analysis of t he ef fects o f ly sergic
acid diethylamide (LSD-25 and d-amphetamine in ma n . At *wg g ^aaaa^eaitfB^
and in Munich
Dr. Pfeiffer is giving a paper on, Further Qua ntitative electroencephalo -
graphic studies: of the stimulant effects of deanol and d-amphetamine in man.
^ - - • •
Abstracts of these four papers are enclosed.
In addition to the above, which are ready for formal presentation,
the following are under way: A number of tryptamine derivatives are
♦
being explored for psychotomimetic and other effects; 4-hydroxy-a-methyl
tryptamine, 4-methyl -a -methyl tryptamine, 6 -hydroxy-N,N-di methyl tryptamine
(The di-methyl analogue of Szara's compound), px'olyltryptamine, psylocin,
and acetyl tryptamine. Results will be reported ^as^T:hey accrue. The
central actions of ^-aminobutyric acid are being indirectly explored by
investigating y-butyrolaetone and y-hydroxybutyric acid. Unlike GABA,
these compounds readily cross the blood-brain barrier, and the:latter is
a potent hypnotic agent and about as active and positive as is chloral hydrate.
1 has rmnrl-f»d an ahnnrir.al FPC Mtnmca
has reported an abnormal EEG response
to intravenous thiobarbiturate in schizophrenic's. Our quantitative method
shows no difference as yet in response between normals and schizophrenics,
to the intravenous injection of thiopental.
S0URCEsV6 MrfTHprfs Ih’VOLVEa-
*T :
5 .
Research Proposals
Tr» the light of the above, the following are planned for the coming year:
1 . Screening of tryptamine compounds in animals and man for hallucino-
genic action. - •;
2. Completion of the study of the use of riboflavin as a trace chemical
to prove the ingestion of medication in a clinical setting.
3. Further studies on the use of phenoxybenzamine and other adrenergic
blocking compounds as antidotes to LSD-25.
4. Further refinement of the use of quantitative brain wave studies to
diagnose schizophrenia and to determine the action of hallucinogens.
5. Selection of one or more of a series of stimulant diamines for chronic
toxicity studies in animals so that they can be tested in normal human
volunteers for possible stimulant action.
6. A search in brain extracts of rabbits treated with Tofranil (iinipra-
mine) to determine if any stimulant amine accumulates as a result of
degradation of the drug molecule in the body.
7. Determination of the anti-cholinesterase and aminoxidase inhibitory
effect of the stimulant diamines.
8. Assay of acet>fcholine content of various portions of the brain after
prolonged administration of deanol.
9. Tire assay in man of an intravenous analgesic solution composed of
morphine and choline or morphine and carnitine wherein the pharma-
cologically neutral quaternary compound prevents the engagement of
peripheral receptors by the morphine.
warning
...
SOURCES Jtr.’Df.JE Ti fcpS<fNVOlVFn
10. The use of stimulants to prevent the blocking of conditioned
behavior .
11. The use of parasympathetic stimulants and methyl atropine to interrupt
trained behavior.
12. A study of prastical drug antidotes to atropine-like compounds,
13. Careful study in normal man of
C
A. synthesized compounds • . . . B
- B.' Compounds supplied
C. Biochemicals purchased
Note: For elaboration of methods see the 1961-1962 proposal.
v I* 'GJt&nhE
sy •p S --K! l !^?^ L ' }G 4ce
^ ■'- ^■xn.'.tTHQOS ifedLVEO
Research Project Application - Pfeiffer and:
Requested Budget
June^l, 1962 through Hay 31, I 9 S 3
O'
Tim e
Principal Investigator, Carl C. Pfeiffer, Ph.D.,M.D. 25%
Co-principal Investigator, 1 25%
25%
Senior Reseorch Scientist
Neu ropharmacol ogist.
Technician
Secretary t
Stipends, Human Volunteers, 50 x 10 x $3.50/wk
Equipment
Consumable Supplies
Travel to Scientific Meetings & Conferences
Amount
$ 4,000.00
3,000.00
None
’ 7,000.00
4.800.00
1 . 300.00
1.750.00
850.00
1 . 900.00
950.00
TOTAL
§25,550.00
In lieu of overhead, the New Jersey Mental Health Research and
Development Fund, Inc. will retain title to any equipment which may be purchased
under said grant. •
I
t
t
r.
7 ? - / ^
£Jufp nf 3/rriiri|
BUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY
c/o NEW JERSEY NEURO PSYCHIATRIC INSTITUTE
BOX IOOO
PRINCETON. NEW JERSEY
JOSEPH M. TOBIN,
DmcaoR
March 2, 1962
t
This brings to mind your promised trip to see our labora-
tory and the progress in our research efforts. We hope that
the month of March will afford you time for such a visit since
we now have much to show you.
l
With best regards.
Yours sincerely,
Carl C. Pfeif/er/ A.D
Head, Section on Pharmacol ocry
Att/*(1) • yx
Period Ending March 1, 1982
Personnel Salaries
and Wages
Travel
Permanent
Equipment
Consumable
Supplies
Other
$1,148.40
*»
$ . iy47
$1,182.44
$ 447.30
$ 45.35
1,070.80
65.09
3,418.78
205.55
4.00
665.40
102 . 94
1,259.65
147.71
56.39
3,492.00
304.61
773.83
157.71
35.05
130.37
621.13
1,095.82
654.93
123.94
$6,506.97
$1,095.24
$7,730.52
$1,613 .20
$264.73
Receipts $30,740.00
Expenditures 17,210.66
Balance
13,529.34
6
&tal* nf Nfia Sfrspg
'll- - I
UUREAU OF RESEARCH IN NEUROLOGY AND PSYCHIATRY
• - C/O NEW JERSEY NEUR0-F5YCHIATR1C INSTITUTE
BOX lOOO.
PRINCETON. NEW JERSEY
JOSEPH M. TOBIM, M.D.
DiACCTOH
.<* March 2, 1982
Attached you ~ will find interim report of out expendi-
tures rrca grant from the period beginning
June 1, 1 SSI end ending Kay 31, 1962.
This brings to irdnd your promised trip to see our labora-
tory and the progress in our research efforts. We 'hope that \
the Jr- earth of March will af ford you time for: such a visit since
we now have much to show you. ^ ^
With best regards,
COP: me
Yours sincerely,
Head, Section on Pharmacology
Period Ending March 1, 1982
. Personnel Salaries
and Wages
Travel
Permanent
Equipment
Consumable
Supplies
Other
$1,148.40
$ . 1:47
$1,182.44
$ 447.30
♦
$ 45.35
1,070.80
65.09
3,418.78
205.55
4.00
665. 4Q
102.94
1,259.65
147.71
56.39
3,492.00
304.61
. 7/3.83
157.71
35.05
130.37
621.13
1,095.82
654.93 *
123.94
$6,506.97
$1,095.24
$7,730.52
$1,615.20 -
$264.73
Receipts $30,740.00
Expenditures 17,210.66
Balance 13,529.34
I
"• jf
* f
-.4- &*- u,^
NEW JERSEY MENTAL HEALTH
v?- ( r
RESEARCH AND DEVELOPMENT FUND, INC.
Trustees
Joseph m. roam, m.d, ca..Vi»m • paul haun. m.d, f;« cA a ;, m „ . henry p. david, ph.d, r™,™,,
V TERRELL DAVIS. M.D. • MAtlRJCK O. KOIT. Ph D. • DOUGLAS H. MacNEIL • LLOYD W. McCORKLE, Ph.D.
. October Z \ 1961
> *
AdArtfit Con e spend. nee to:
Ileniy P. Dtvid, Ph. D.
Stcretiry Trtuuref
1 JillUne
Trenton 8, N. J.
Dear Dr.
It l 3 ,. Wi M? pleasure that I acknowledge your recent
conurioution of §15,370.00 a. a the first payment
on wie new grant under Dr. Carl Pfeiffer.
Yours sincerely,
Ikvowa
Henry P. David, Ph.D.
Secretary Treasurer
HPDicf
cc; Dr. Carl Pfeiffer
Confxfcufionj DmSuchble lot Ft-dtral Income Tat tor po art.
l~f
V?-/?
RECEIPT
Receipt is hereby acknowledged of the following two checks:
Treasurer 's Check No, lBktfk, dated July 26 , 1961 , drawn on the -
Jxi the eaouat of $1,229.60, payable to
?0
Check No. 26T$69, dated. July 26, 1961 , drawn on the
$30,740.00, payable tTtte
to Carl C. Pfeiffer, Ph.D., M.D.
i960 to Ha/ 31,. 196l . . . .
jith llew Jersey Mental Health Research and Development Fund as the Recipient
Receiots
September
January
$2l*,7h9.00
ip, 37^.50
12,37l|.50
Total receipts
$l*?,li98.00
Expenditures
Laboratory equipment and supplies
Office equipment and supplies ^
Salaries and vages
Travel
$38,63?.6l»
6,018.57
2,888.86
1,555.38
l*o 2.55
Total expenditures
*l49,J49S.OO
^ C-
cc. Joseph* M. Tobin, Director, E-ireau of Research „ .
David Henry, Sec. Treas., Hew- Jersey Men tal Hea lth Research and Development r y nd
f.
T
,;.- -'-^^v- Vj'i, ...*„. <V- „ , W,-C>'- fe\ i& .j» L&V-4 C^*- ?
?
u>
NEW JERSEY MENTAL HEALTH
RESEARCH AND DEVELOPMENT FUND, INC,
HP - *-i
7*twi/«# -
JOSEPH M. TOBIN. M. D, Chairman * PAUL HAUN. M. D, Yk§ Chairman • HENRY P. DAVID. PH. D» Secretary Tteanjrar
V. TERRELL DAVIS, M. D, • MAURICE G. KOTT, Fh.D. • DOUGLAS H. MacNEIL * LLOYD W. McCORKLE, PH. D.
K
A33rtn Correspondent* td:
Htmy P. D#vid, Fh. D.
Secretary Treasurer
] Jill L*n»
Trenton 8* K. J.
May 12, 1961
It la a ple asure to a cknowl edge receipt
of your check in the amount of twolvo thousand
three hundred seventy four dollars and f 1 f ty cent a
($ 12 , 374 * 50 ), representing the'fourthquarterly
pay nent supporting the research program of Dr. Carl
C. Pfeiffer.
Yours sincerely,
Heni'y PT Dsvldy Ph.D.
Secretary-Tr eas urer
HPD/lm
CC: Dr. Carl C. Pfeiffer
Dr. Joseph Tobin
Jtre- for F*\fcr») Jmtorr* Tst
0
C;
V?
IKVOICS
For Service 3
$31,969.60
« • * ■>
N CErv-rmCATIONS
(l) It is hereby. certified that this is lovoice J^epplylng to euVproJeet
Ko. ‘ i ' of liKULTRA, that performance is satisfactory, that services are teiog
ftcconpi 1 shed in accordance vith mutual agreements, that a detailed agenda of
the payments and receipts is on file in TSd/KB, that this bill ie Just aDd
correct and that payment thereof has not yet been unde.
Chief, TSD/Re search Branch
Date:
47
(2) It. is hereby certified that this invoice applies to Subproject
of MXULTRA vhich vas duly ap proved , end tha t the project is being carried out
in accordance vith the meoorariduin of 13 April 1993 fron the DC 2 to the DD/A,
and the extend on of this authority in subsequent tr-e-corands.
Research Director
Date:
.s-^-c-tris-T"
, lM „t p ,, • *.*••*» j*t- », ;
i*
1 1 7-i^i
| June 1961
memorandum for? comptroller
A'vtv'NTION ‘ : Flntbce Division
attention
SUBJECT
MKULTRA, Subproject 41, Additional
Authorisation No. 9
Under the authority granted In the memorandum dated 13 April
1953 from the DCI to the DD/A. and the extension of this authority
subsequent memoranda. Subproject 47 has been approved and . ....
53t.969.69 of the over-all MKULTKA project funds has been
obligated to cover the subproject expenses. Thts obligation of
funds should be charged to Allotment 21:5-1390-3903.
APPROVED for obligation
OF FUNDS:
Research Director
\l$*'
Date:
Distribution:
Orig & 2 - Addressee
1 - TSD/OC
J^TSD/FASS
2 - TSD/RB
gggStfe«8#§Si3lit.
Chief,
TSD/Rcsearch Branch
AVAl'-A&lC
I cCRT' r » 1 ! ’ M r ' ' „ r
c , A tC 10 AUO-'b-’
Q*nCtft
t
proposal
simiFCT' The Testing In Animals and Human Volunteers of Chemicals
and Biochemical* Which Alter Behavior.
PLACE: The New Jersey Neuro-Psychiatric Institute
' The Bureau, of Research In Neurology and Psychiatry
Princeton, New Jersey (P.O. Box 1, 000)
PRINCI PA L I NVESTIGATO R: Carl C . Pfeiffe r , Ph. D. , M . D.
GRANT ADMINISTRATORS^ NewMersey Mental Health Research and
~~ ' Development Fund, Inc.
I Jill Lane, Trenton 8, New Jersey
Henry P. David. Ph.D., Secretary-Treasurer
It Is proposed to conduct screening and range finding tests on volunteers
with chemical compounds of known behavioral activity.: Studies will be
conducted on derivatives of selected biologically active compounds to deter-
mine their action on the central nervous system of man.
In addition to these Investigations, the following work will be undertaken:
1. Pharmacological testing will be conducted on animals
utilizing candidate hallucinogenic chemicals,
2. Studies will be conducted on compounds of relallvly
simple configuration to assess their ability to tnhlbit trained
behavior In animals utilizing the condition avoidance responses.
3. Studies will be conducted of compounds In normal human
volunteers for possible behavioral changes utilizing compounds
provided by the sponsor.
4. Quantitative studies of the EEG in animals and man to
determine stimulant or depressant effects of candidate mater-
ials.
IPTiPiEO FOB PAYMENT OP CWEPtT
icxAtuMC of cenrifviwo office*
I
r -
12 July 1961
MEMORANDUM FOR: Chie£ Finance Division
YIA * TS D/Budget Officer
SUBJECT
I MKUI/TRA, Subproject 47, Invoice No. 12
Allotment 2125-1390-3902
i- '
. 1. Invoice No. 12 covering the above sub project is attached.
Payment should he made as follows:
Cashier’s check In the amount of $30,740. 00 drawn on a
Cashier’* chock in the amount of $1, 229.60 drawn on a
Check® should be made payable to the
i&T ‘ .
JB
2, Please foruurd the checks to Chief, ;TSD/Reseatch Branch
through TS D/Budget Officer by 24 July 1961.
}, This is a final invoice. However, cine o it is anticipated
that additional funds will bo obligated for tl.ia project, the flies
should not bo closed.
Attached:
Invoice t< Certifications
Chief
TSD/Rescarch Branch
Di 6 tri button:
Orig fe 2 » Addressee
. i
I
i
it- r
' I ?- >- 1
26 April 1961
MEMORANDUM FOR*. Chief, Finance Division
VIA j TSD/Budget Officer
ciirTFCT : MKUETRA, Subproject 60, Invoice No. 1
SUBJECT . Allotment 2125-1J90-J90Z
I. Invoice" No. 7 In the amount of $18. 500 is
due to refunds of $ 5 , 582. 12 from this and one other project (as pe
attachments) payment should be made as follows.
Cashier's Check inthe amount of $12. ?17. 88. drawn on a
f".,b>„V. payable to .he Socf.i/foV lb. Inve. ..gallon of
- Human Ecology,' Inc. ~
J. The check, ahould bo forwarded to C ^ lef -
Branch, through TSIS/Bndget Offlcor. no latof than Monday, *M y 1 .
J TM. I. a final Invoice. How evtr. itnco it I. anlldfatcd ^
that additional fund, trill be obligated for thl, project tha file, .bou i
not be closed.
Chlei ^
TSD/Research Branch
Attachment:
Invoice k Certifications
Distribution:
Or Ig k Z - Addressee
7:j‘3G
.•*J* *?.** f * 't, f »•* '**j»»* t* •• • * * *• i# .»»•? •«•;■
T'-i .
r :
7 ? - >©
proposal
SUBJECT- The Testing In Animats and Unman Volunteers of Chemfcals
— ^ and Btochcmlcals Which Alter Behavior. .
& rp. The New Jersey Neuro-Psychiatric Institute
PL - ACF - The Bureau ol Kesearch in Nenrology and Psychiatry
Princeton, New Jersey (P.O. Box 1, 00D)
PRINCIPAL INVESTIGATOR: Cart C . P feiffer . Ph.D.. M.D.
r^r AnMTM STRATORS: New Jersey Mental Health Research and
■ — — — - Develop ment bund, Inc.
f=j 1\ 1 Lane. Trenton 3 . New Jersey^
Henry^P. David. Ph.D., Secretary-Treasurer
1. is proposed ...ondncd sereeMng^nd ™
Motoglealty net.ve ecnpour.ds to deter-
mine their action on the central nervous system of man.
addition to these Investigations, the following work will be undertaken!
1. Pharmacological testing will be conducted nn animals
utilizing candidate hallucinogenic chemtcjUs.
' 2 Studies will be conducted on compounds of relatlvly
! sim!t'e cln guration to assess their abtlUy to Inhibit trained
| . ulhavtor In animals utlllalng the condition avoidance responses.
• 3 Studies will be conducted of compounds In normal human
- volunteer s^for possible behavioral changes u, Hiring compounds
| provided by the sponsor.
i 1. Quantitative studies of the KEG in animats and man to
: determine stimulant or depressant effects of candidate mater
lats.
'Dc - i'ncra2ed W CtfrtPS&RTIAL
^y^ouynariVy y* •/ 1 ^f 7 ^J
12 i.'X^f;
'byUSY'mS
DRAFT
1 J une 1961
MEMORANDUM FOR: THE RECORD
SUBJECT
MKULTRA Subproject 47
1. The purpose of this subproject 47 Is to provide funds to continue
a research program being carried out by Carl C, Pfeiffer, MD.
2. The nature of the investigations to be carried out under the
direction of Dr. Pfeiffer encompasses pharmacological and clinical
testing in animals and human volunteers of chemicals and biochemicals
which alter behavior. Certain phases of other problems of interest to
TSD will be Investigated. — - - =. — '
3. Dr. Pfeiffer is located at the New^Jersey Neuro -Psychiatric
Institute in the Bureau of Research in Neurology and Psychiatry, Princeton,
New Jersey. j3
4. The funds for this project will he transferred using
mmm
as a cut-out.
5. The cost of this program for a period of one year beginning 1 June
1961 will not exceed $30,740.00. To this sum must be added $1. 229.60
representing a service charge to the ^
m
Ei v:S^
making the total amount $31,969.60. Charges should
be made against Allotment 12125-1390-3902.
6. The New Jersey Mental Health Research and Development Fund
Inc., who administer the grant have agreed to provide
t^$^witKa summary accounting on an annual basis of all monies received
•dWcCiiMilAt
5BIW
<b o
Dims
' ‘ “ E2 IiMfij CL BY. 167475
from th They have also agreed to return any urtexpended
funds to theid^^^^^gaagas soon as possible upon the close of the grant
year.
7. The requirement for a six months' informal accounting on the part
of the principal investigator is waived.
8. /Title to any permanent equipment purchased by funds granted the
f •>»
V-
New Jersey Neuro-Psychiatric Institute shall be retained by the Institute
in lieu of high overhead rates.^
9. In connection with travel under this project, it is agreed that the
Agency will accept the travel documentation and accounting which conform
with the practices of the New' Jersey Mental Health Re search and Development
Fund Inc.
10. It is agreed that technical rep orts r ef lectin g t he progress of the
research program shall be submitted at mutually acceptable intervals.
11. Dr. Pfeiffer has signed the Memorandum of Agreement and holds
a TOP SECRET Agency Security Approval,
APPROVED FOR
OBLIGATION OF FUNDS:
A
TSD/Research Branch
Attachments:
Proposal & Budget
Distribution:
proposal
• ■ Animals and Human Votunteers Of Chennicals .
SUBJECT: rhc ^chemicals Which Alter Behavior.
PLACKj At. ^
<p -°- Box , ' ##0 ‘ . '
pmNCIPAI,INVKSIIOATOBj Cart C. P/eitfer, >>h.D.. M -°'
4
It is proposed to conduct screening will be
-«» T" con ’ pwn< ’ 5 10 """■
rntttTcUon t «.e centra, nervous system of «.
addition ,o these investtgattons. .be lowing worb
, Pharmacological testing fill be conaucteg on anunats
utilizing candidate hatlucinogcmc cbcmtcals.
2. Studies will be cond “' ,e f h °J r \°bmty"o* nMbil trained
simple configuration to , Wo / avoi g a „ c e responses.
behavior in animals utilising
provided by the sponsor.
. . ppp * i« anitfijls and man to
4. Quantitative studies ot the t , ot cBn dWale matcr-
de, ermine stimulant or depressant effects o
file
‘ Research Project Application - H elIir
Requested Budget
June 1. 1 9bl_ thru H ayjl , 1962
TITLE
Principal Investigator Carl C. Pfeiffer, Ph.D., M.D.
M.S.
Senior Research Scientist,
Paid by State of New Jersey
Clinical Pharmacologist, Ife
Neuropharmacologist,
Technician & Animal Kan,
C...
Stipends - Human Volunteers
Equipment
Consumable
for ESG
Supplies: Animals, Animal Food, Biochemicals, Paper
Travel to Scientii'ic Meetings & Conferences
TIMS . AMOUNT
§ lj,000.00
2 $% None
75*
$0%
100 *
y$%
10 , 000.00
6 , 000.00
lj,l60.00
1,280.00
1 , 500.00
None
TOTAL
3,1400.00
ij 00.00
■530,710.00
I. lice f cverteea, tte ^ *“
retain title to any equipment uhicn may y
5/61
receipt
, A nf the follovtins >»° tht ' CV,:
: t.e hereby o! <■>«
Receip _ , drawn on .
omciai check
i- ■ >) iqAO drawn on
off . cUl check tfo. ^ ^ the amount of
L e‘ * -. .SeAeVI^ - , j
>K* .^rtf ’ fss - ’# i i'~r**SV'
^*S55SSfl> -
I
•- r..
29 June I960
MEMORANDUM FOR: CHIEF, FINANCE DIVISION :
VIA I TSP/Budg et O fficer
SUBJECT
; MKUI.TRA, Subproject 47, Invoice III
Allotment 0525-10Q9-49Q2
1. Invoice 111 covering the above eubproject i* attached.
Payment ehould be made as follow*:
Cashier'* check la the amount of $49,498. 00, drawn
Cashier's 'check In the amount of $1,979.92, drawn
Each check should be made payable to t h e - - - -
2. Plea,:© forward the checks to Chief, TSD/Rescarch Branch
through TSD/Budget Officer by 15 July I960.
3. Thl* Is a final Invoice. How«ver,Tlnc« It I* anticipated
that additional fund* will bVobHk ated'for thI » proj ec t, the file*
should not be do* ed. 1 : .
Attachmeot;
Invoice It Certification*
Distribution;
Orlg h Z - Addressee —
1 - TSD/F ASS
^2^TSD/©B
Chief
TSD/Rescarch Branch
C~'
’ 1?-*3
INVOICE
For Service*
3 >
CERTIFICATIONS
j (1) It Is hereby certified that thi* Is Invoice #11 applying to Subproject
| 47 of MKULTftA, that performance I* satisfactory, that service* are
{ being accomplished In accordance with mutual agreements, that a
{ detailed agenda of the payments and receipt* is on file in TSD/RBr^v
! that tbi* bill i* just and correct and that payment thereof ha* not
j yet been made. - ^ ^ ^ ^ ^
$51,477.92
Chief, TSD/Research Branch
Date:
(2) It is hereby certified that tht* invoice applies to Subproject
No. 47 of MKULTRA which was duly appr ov ed, and that the project ^
is being carried out in accordance with the memorandum of 15 April 1955
from the DC! to the DD/A, and the^xt^nsloaTof thl* authority in subsequent
memoranda. ~
Research Director
Date:
» .\U' ■«v tv ‘iv ^
~0
DRAFT
20 May I960
MEMORANDUM FOR: THE RECORD
SUBJECT
: MKULTRA, Subproject 47
■ - j. The purpose'-of this subproject »9 to provide funds to continue
a research program being carried oat by Carl C. Pfeiffer, M.P.
Zi The nature of thF investigations to be carried out under
the direction of Dr. Pfeiffer encompasses pharmacological and
clinical testing in animals^nd human volunt ee rs of chemicals and
biochemicals which alter behavior as outlined in the attached proposal. ,
3. Dr. Pfeiffer was previpusly'ldcaVcd at the Emo ry University,
Atlanta. Georgia. HeTs now located at the Kew Jersey Neuro-Psychiatric
Institute in the Pureau of Research in Neurology and Psychiatry, Princeton,
New Jersey. This change in position will not in any way interfere with the
#
Agency sponsored work, in fact, Dr. Pfeiffer will have access to more
and better equipment and personnel for his researc h.
4. The funds for this proj ect will be transf erred using the
5. The cost of this progra m for a period o f one year beginning
1 June I960 will not exceed $49,498. 00. To this sum must be added
$1,979,92 representing r. 4fo service charge to the|i
r: / :c3 * 6 : JfcWj.W
j/bT^tc 75
Mental Health Research and Development Fund, Inc. , who administer
the grant, to submit to^tbem a summary accounting on an annual basis
.t
of all monies received from the Fund. Also, it has been requested that - ^ ^
any unexpended funds be returned as soon as possible upon the close of
the grant year. —■ ^ .
7 The requirement for a six months' informal accounting
’ - i *
oo the part of the principal investigator is waived.
f
8, Title to any permanent equipment purchased by funds
i •
granted the University shall be retained by the University in lieu
of high overhead rates.
9, In connection -with travel under this project, it is agreed
that the Agency will accept the travel documentation and accounting
which conform with the practices of the University.
10. It is agreed that technical reports reflecting the progress
of the research program shall be submitted at mutually acceptable
. intervals.
Q - 3 - 0 y?- ?y
Pfeiffer has signed the Memorandum of Agreement
and holds a TOP SECRET Agency Security Approval,
A
Chief
TSD/Chemical Branch
“ *» %
APPROVED FOR OBLIGATION
OF FUNDS:
Attachment:
Proposal t Budget
Distribution:
Original only.
C ' ■,
C*
v v
■MfcWStSgJ
RESEARCH PROJECT APPLICATION
The testing in animals and human volunteers of chemicals and bio-
chemicals which alter behavior. .-- r
PLACE; The New Jersey Neuro-Psychiatric Institute
The Bureau of Research in Neurology and Psychiatry
Princeton, Mew Jersey (P. 0. Box 1,000) .
PRINCIPAL IN VESTIGATOR; Car l C. Pfeiffer, Ph.D., H.O.
. GRAN I A ON IN I S T PA T ORS^ New Jers ey Me n tal Hea l th Res ea rch and Development Fund, Inc.
I Jilt Lane, Trenton 8, New Jersey
Henry P. David, Ph.D., Secretary-Treasurer
3 *
INTRODUCTION: The «3gg%j%gg£ggg^i has aide d the research studies of the principal
q i iA.ii M.uyio gf tne principal
investigator for more than ten years, during which time many notable advances have
been accompl ished. 1 £
At present the supports the search for newyKal luci nogens (chemically
simpler than LSD~Z5) . These are synthesized by-^^S^ tested in animals and in
JdlJLES systems and then cautiously tested in man. is taking a leave Of
absence ne xt^jf ear end will work in 195T as head of medicinal chemistry in the
His synthetic work wi II continue in
1961, and in ISi0-JS6l we wiif test the backlog of compounds already synthesized.
The grant to Emory will terminate as of Hay .31, I9S0, which is the close of the
presen t grant year . Other funds are available at Emory to continue the testing
of t he ^^^ ^co.r'pounds at the Atla nta federal Penitentiary under the direction of
H.D. from the period June 1, to December 31, I960. By
this. time the human testing will be organized and progressing in New Jersey under
the direction of the principal investigator. On July!, 196 1 40SS B&$g* *f ^- wj | j j£
have completed his. last six months of a split internship and will join the research
team in the New Jersey location.
SENSITIVE
> JRCES AND
RESEARCH PR OPOSALS;
A. Pharmacological testing in animals of candidate hallucinogenic chemicals.
B. Study-of simple compounds which may inhibit trained behavior such as the
conditioned avoidance response. .*
C. Careful study of compounds in normal human'volunteers for possible behavioral
changes: .
1) «^||5!8^synthesized compounds
2) Compounds supplied by B
3) Biochemicals purchased
NOTICE
ENCE
OLVEO
iUJU..*
•3
o
o
Research Project Appl ication - Pfeiffer
- w
page 2
0, Quantitative studies of the EEC in animals and man to determine stimulant
or depressant effects.'
E. Annual conference on the neuro-biology of psychoses.
Er
Proposals A, 8, and C are a continuation of th e/kork now in progress which
is familiar to the officers of The from our annual and semi-
annual reports. Under C th^'source of human volunteers wi 1 1 be the 100 reformatory
inmates (ages 18 to 28) whobre stationed on the grounds of the Institute. If 16
volunteers, aged 21 to 28,- are not obtained frcm this group for a weekly session
of drug testing, we will have one session of eight subjects at the institute and
one session at the New "-'Jersey' State Prison in Trenton. ‘^Commissioner 8rafnberg has
given his permission.
Under £ we now have perfected and plan to use at the New Jersey Laboratory a
quantitative integrator for drug studies in both man and animals.
Adult unanesthetized, trained animals are used. Under anesthesia small gold-
plated wood screws are used as dural electrodes. These are lightly engaged in the
calvarium and held firmly in place with methacrylate with the permanent lead .
attached. The recording leads are bi^pbiar from the left and right frontoparietal
lobes of the brain. The animals are in a sound attenuating box and sit quietly for
the entire 1 to 2 hour session after a few training periods.
A CrohocW integrator is attached to one lead. This device rectifies the brain
waves and by a chopping process, counts the area under the rectified curve. A .
signal is made at a pre-set degree of sensitivity. The number of signals per unit
time is a measure of the degree of electrical activity or ."electrogenesis. 11 The
number of pulses or signals is directly correlatable^wi thT the area under the curve.
The constancy of the electrogenes is with elapsed time can be calculated and treated
by the usual statistical methods. In this type of analysis, periods as long as
five minutes can be used as a baseline or control and thus transient artefacts are
eliminated. The action of drugs is usual ly measured at ] -5 minute intervals after
intravenous injection and the drug action is expressed as change in percentage
electrogenesis from the control preinjection period. Arousal or stimulant drug
effects are recorded as a decrease while sleep (sine yvaves) produce an increase in
electrogenesis.
E. Annual conference on neurobiology of psychoses. Most previous conferences
of this type have been poorly planned, and the group has been too large and unwieldy.
Money spent on verbatim recording and publishing is wasted, end this' process further
inhibits the participants.
The participants will be limited to 12 or 15» The record wiil.be in the form
of the individual’s own notes and the notes of a scienti fical Jy trained secretary.
The summarizing secretary will change with each three-hour session. In a two-day
conference we would have five sessions of three hours each. t
^ The coo f c r ence^^ou M, the
with a biological approach to mental disease would be' invited. The ^ ■
various basic disciplines would be represented. Some of the participants might be L —
... * ±.
“Tr——
o
S^tiTpriJStt Application - Pfeiffer
O YT 3 *
: ' - page 5
Prior to the meeting a questionnaire on P° s5 ^ e ^"[.‘’^“^[“to'thLe possible
^ ths - iority of .‘ he ,act °"
diSC >osJ:blc biological factors which will be IacHkM In the goestionn.l re are for;
A. The
“D
2 )
3)
4)
5)
6 )
7)
8 )
9)
10 )
11 )
12 )
13)
14)
15)
16 )
17)
18 )
19)
20 )
21 )
22 )
23)
S ch 5 z ophjr en^as, (assuming a heterogeneous clinical entity)
Defective keto-acid utilization
Defective carbohydrate utilization
Decreased level of-blood glutathione
Therapeutic effect of intravenous glutathione
Increased ascorbic acid requirement ^ .
Increased ceruloplasmin in acute sch.zophrem
Therapeutic effect of ceruloplasmin
The effect and role of Taraxeifi .
Increased adrenal cortical and medullary activity
Increased urinary catechol amine excretion
Increased urinary indole excretion
Epinephrine metabolism
Serotonin
Estrogen-androgen function (moro common in female!)
ti”«^Ie«vlW*lhlp|»r.e-cta synthesis) Co-entyme A
Effect of growth hormone
a) Occurs when somatic growth stops
b) Post-partum psychosis
cl ACTH psychoses
Childhood autism and the adult schizophrenics.
Pi ncal gland extracts _
The schizophrenias in the blind
Sensory deprivations and psychosis
EEG abnormalities
a) Heath's septal spikes
b) 14 and 6 disorder
2*0
25)
26 )
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
b) m ano o oouiwi . .. ..
6i l s r^:;ic.i:cruUiii y .hr r ^/(:Ln 9 « >
Specific effects of phenothi azi nes
Specific effects of reserpine
Specific effects of deanol
Porphyrin metabolism
Thioctic acid
■funker.steln tests .
Response to histamine and al, . e ''?'“
Overdosage of amine oxidase inhibitors
Influence of tuberculosis, influenza, etc.
Soma toty pcs
Depressive ps ychos es
lT~Arnfne oxidase inhibition . ..
2) Action of electroconvulsi ve, therapy or insulin
3) De-anol therapy
4) Blood butane - 2, 3*diol levels
. 5 ) Somatotypes
C. Manic psychoses
1) 'Effect of lithium
2) Metabolism of uric~?cid
3 ) Hyperthyroid mania "*
4) Neuraminic acid .
5 ) Catechol amine excretion
6 ) Indole excretion
7) Bloodacetoin levels
8 ) Effect of phenothiazines
9) Somatotypes
1
* A . ir ri -j --.j, 3 .* ■
Res earch Proj e c t AppliXtion - Pfeiffer
. budget
Principal Investigator, Carl C. Pfeiffer, Ph.D., M.D.
Research Psy chopha rma c o 1 og i s t ,
Clinical Investigator (H.D-X'
»-
Stipends, Human volunteers -
Technician
Secretary
Animal Kan
i
O.A.S. 1 .
-SV
page 5
Time
, M.D. 25 %
.■ 4,000.00
^t^M.S. 100%
7,500,00
100%
12,000.00
4 , 000.00
100%
4,500.00
50%
2,000.00
50%
1,500,00
648.00
Equi pment
2 Electrified conditioning cag es for an imals <3 $ 250.00
1 Constant intravenous infusion pump
1 Polygraph Grass 4 channel with stimulator and transducers
Consumable Sup p l ies
«
Animals, animal food, biochemicals, paper for CC6
Travel - To scientific meetings and locally to -Trenton State.
‘Prison and^ospl ta 1 ;_
Miscellaneous - Photographs and reprints
Conference on neurobiology of psychosis
500.00
350,00
4 . 600.00
h, 000. 00
1 . 500.00
\
‘ 200.00
2,000.00
549 , 493.00
|„ lieu of overhead '.he Kew Jersey Hotel Heel th Reseer.h end Oe,el, opi»e« Food will
retain title to all permanent equipment purchased under said grant..
The above grant is requested for the period June 1 ,'ISSO through May 31 , > 961 . •
wa^ni n0/qtich: ^
sEfpTi7^a liu&v/.oz
SOURCES AUjj
aassaan&Hti
v*.-- •• • ■* * 1
'X.
r
f\ - -
1 V? *
20 May i960
MEMOS AN DUM FOR *. COM PT ROLLER
ATTENTION : Flnaoc® Division
SUBJECT
• MKULTRA, Subproject 47, Additional
-'AutKoriaatlon No. 8
Uoi.r tk. .otfcotHy jrwled W tb« rawn.r.aJum d»l»J
U April 1955 from tk. DCl to Ik. DD/A. aid <>>« »' ,M *
a.tkorlty !» ..Vl.qu«t «»»»•*. Sokproject 4' k »' l '*“
approved And J51.4J7.92 of Ik. ov.r-All MKULTRA proj.o. food.
1 .. k.e. obligated lo cover Ik. .okproj.cl «*?<«•*•■ tkl.
obligation Of food, .hoold W.harged <0 Allotment 0525-1009^1902
TSD/Cbemlcal Branch
approved FOR obligation
OF FUNDS:
■
Research Director
Date:
Distribution:
Orlg U 2 - Addreiae*
l - TSD/OC
1 - TSD/FASS
2 - TSD/CB
TSD/CB/!
Pi
ir
/
^wJULU,«jimiUnHMHMR
O
CT
S-ORY UNIVERSITY
V>-?*
^SSSs^s;
3>
Department of Pha rr.2 c o lo-y
Dr. Carl C. Pfeiffer, Director
1 • -
nt x - -
»•
Snrrsary of R eceipts sad R-roenditure s for the Period
Tune
t'.iouh Kay 31 . I?o0
\b
Received
. I059-0O
*DIR3CP KXP^roiTURES:
Personnel
Fellowships
Eu.:»an Subj ects
Travel
$23,359-39
7,300.00 :
3,310.00
2,919.36 .
Equipment ~ 1,005.68
Spendable Supplies " 2, 773. 99
Toiel Direct gxo enditures $4.3, 669.1 8
Indirect Costs
TOTAL EffFNDITuRSS
*See attached schedules
‘ U.RSS.S4
$»t8,C35.26
$48,377.50
Approved:
Csrl C, PTciffc-r, y< y 0.
•Project Director '
, . . - ....5 .i n sjt-itted
“'il as c*. >•*- ^
1 hive -r.cu
A
(mt.t V‘A
r ■* 1-1 Division
• V-.-- •
H-DBY UNIVERSITY
“C
w ?
Department of Fhanacology
Dr. Carl C . Pfeif fer, Director
^r.olovee
Annuity--
PERSQIStEL
Posi tion
Research Assistant
Research Assistant
Instructor
Assistant Professor
A s si s tant Professor
Associate Professor
Research Assistant
Research Technician
Assistant
Research Technician
Technician
Research Technician
Anii .al /.'ttendant
Assistant
Social Security
Araoun t
$ 22^2.
3630 .
300.
300.
8916.
900.
1040 .
22U0.
13.
’1075.
99 -
1050.
390 .
669.
14 .
$ 23359 .
FELLOWSHIPS
Fellow
Fellow
Fellow
Fellow
Fellow
Fellow
300.
300.
. 2500 .
^JOOO.
f 7300.
Ha-an Subjects
1
88 8 8ft8 83&8*8 8 88S)S 8 88 8 8 818
O
o
HT- 3 (-
52-DRY UNIVERSITY
KUIPISIT
PTE'S
Fj Via ba&se service
Refund of customs
Parts for typewriter & film editor
Freight
Chair
Dynamometer
Auto calculator —
Battery "booster
Spec Irophotometer
Vacuum cleaner
Electroencephaloyraphic
Instrumentation aids
VO. NO
AMOUNT
sj-?-49
$ 52.75
o .6-31-59
(43.09)
85143
68.95
85723
4.92
66119
23.25
S5S&4
91.39
92866
1,009.40
92575
11.31 -
94485
1,000.00
94506
36.02
95829
Total- ;
? .4,005.08
■
o
'""'O'
J2-DRY imVKRSm
D epartment of Pha rracolo^f
Dr. Carl C. Pfeiffer. Directo r
SUPPLIES
Services rendered . -*
Reprints
Ileedles
Reprints
Pharmaceutical supplies
Preparing infrared absorption spectr
Book
Statistical tables
Book
Medical illustrations
Photocopy
Misc. supplies
Saws, saw sharpened
Reprints
Mold release
Office supplies ;
Hultilith service
Multilith service
Pipe
Book
Fnamaceutical supplies
Electrodes, potassium hydroxide
Reprints
Chemicals
Graph sheets
3ook
Freight
Medical illustrations
j>0O:IG
Chemicals
Filter py»p, "conderscr and fittings
Medical illustrations
Medical illustrations
GlJtam.ir.e
Cleaning supplies
Mi.sc . supplies
Ivans distance telephone
Electrodes
He.nolcts
VO. RO. '
76391
76733
707377
7»923
SJ-6-70
a 77681
7867O
7S6S9
79170
JE 781
SJ-7-5O
79354
60177
60709
60745
SJ-8-65
SJ-e -71
SJ-6-71
SJ- 6-104
81761
SJ-9-26
-82487— - ;
82823
82853
63425
63936
«JE- 10-82.
£4372
£4241
655575
JE-n-52
OE-12-43
67086
SJ-12-79
87516
SJ-12-74
asm
86170
AJDuRT
♦ c
. 18.00
57.68
3.7I
68.60
7.32
6.00
5-4i
4.39
8.93
59/50
1.00
7.12
11.64
33.90
5.84
8.80
33.63
82.25
2.42
5.34
20.34
37.29
10.40
15.60
9.57
20.39
9.94
6.00
13.91
13.92
' 52.53
9.00
16.00
19.57
17.51.
3.62
2.30
46.30
12.36
(continued on page 2)
o
u
y? - &
(page 2 )
ITEM
VO. NO.
Reprints
Riarnaceutical supplies
K» se . supplies
Reprints
Copper tubing
Kedical illustrations
T*’g chinpanzees _
Km ivrrc eut ical supplies
Long distance telephone
Kisc.lsupplies
Kisc. supplies
Plugs, receptacles
Flas'xs, chemicals
Rabbits
Ice
Rio to supplies
Kidical illustrations
long distance telephone
Enaxxiaccutical supplies
Kisc. supplies
Drugs, chemical s
Rabbits
Eeparin.KA.
Key or t cards
Ice
Chemicals
Ear
Chronosorb
Keedles
Chemicals
Graph paper
Plexiglos
Publication
Kisc. supplies
Rabbit pellets
Rabbits
Animal food
Publication
Kisc. supplies
Anirral feeders
long distance telephone
Fhnrr.aceutical supplies
Ice
Syringes
Knife blades
I!isc. supplies
Drying jar
88860
SJ-1-82
9122 ?
91531
SJ-2-84
JE-2-43
SJ-2-42
sj-2-79
sj-2-48
92323
92914
92939
92989
93105
93217
93592
JE-3-43
SJ-3-62
sj-3-64
93919
94055
94076
94132
94384
94394
94402.
94448
94449
9450!*
94559
95033
95045
95169
951&7
95201
95217
95381
95437
sj-4-61
SJ-4-67
sj-4-54
sj-4-69
95837
99876
95923
95992
96000
*
$
AjMDUKT
32.09
18.20
1.85
IO.67
6.73
76.50
300.00
53.75
1.90
10. 5 0
39.82 .
64.40
22.25
51.50
19.78
73.93
77.25
14.45
63.21
24.15
63.91
77.25
13. 9T
13.34
20.62
176.58
5.57
8.61
7.67
15.06
9.89
18.99
2.49
6.00
34.18
25.75
29o8
;5-39
4.72
38.47
4.65
7.42
24.91
10.30
4.24
3.00
20.19
c
(pa^e 3)
1TH4
VQ^IiO.-
90 OI 3
Cvlinaers, beakers
96488
Mice
96637
j* 5 * *:Rzine "bound.
96700
Aninal food
96778
Foriaic 3 / ci ue J
96883
Ice
97302
Ice
sj-5-78
Animal feeders
9 S 2 S 3
IJeedles . • '*
96012
Overhauling typeuri^er ■
99308
ca '170
Heedles
Dry ice
Anicv?.l feeders
SJ-680
$
71.18
101,17
34.7f
78.28.*
22.97
io,crr
10.29
7.84
1.92
19*50
9-59
20.05
l.oS
V? 'V
Toial
EMORY UNIVERSITY
Atlanta 22, Georgia
<4^#,.. .^..-4*.’?. it vji i J&.iU'&Sii- A.' .”7
f) ■
V? - 3?
Division of Basic Health Sciences
March 28, 1950
Ornct of the OmecroR
f{ Oea r r||^p§£p|»
Attached you will find our research proposal for the year 19S0-19&1*
We hope your reviewing board will look favorably on this application.
If the grant can be activated as of June 1, 1950, we shall be able
to order certain items of equipment and thus decrease the delay which
nay result in changing our labora tor ies. I shall begin ,
Jersey as of July 1, 19507^1 f you or the officers of
have any questions, I shall be glad to appear before your group
tcrexplain or justify any of the budgetary items or expand on the
details of the proposed research. ^ ^
We are proceeding with the testing of the compounds which%p| has
submitted. ,
Yours sincerely,
^ si'D/ './J
7
Carl C7 Pfeiffer/ M.O.
CCP:cw
EMORY UNIVERSITY
Emory University. Georoia
Division of Basic Health Sciences
November 20, 1959
Office of the Director
Attached yoe will find . copy .Tjur budget
1959 with encumbrances- projected for the grant unti I
the report you will note that that the grant .from _ the °
U. bltng spe^ according to schedule and will be used up as of June I,
I960.
Payments are ccu.pl die as of the present date, but a guarterly payment
will be due Emory University on December 1, 1959-
. , -ii report for the first six
months Z Tepoct of penitentiary will be
sent to you early in December.
, ’ Yours sincerely.
Carl CrPf^ff/r/H.D
CCP:cw
ca i?y
wmrnmmsassssmmimmK',
Emory University
Emoht University. Georgia
V?- 3f
Office OF THfi CoNTftOLLER
October 5/ 1959
I
I
Gentlemen:
We enclose the original and one copy of our
report of receipts and expenditures in connection
vith the gmnt to Enory University, under *he direcvion
of Dr. Carl C. Pfeiffer for the period June 1, 19>°
through Kay 31, 1959 « =
Kindly inform us if this report is not satisfactory.
Very truly yours.
•/. , /
Ralph C . Davis
/ Chief Accountant
r
PCD: dp S ^
Ends;
cc: Dr. C. C. "Pfeiffer
\
r ■
EMORY UNIVERSITY
l yrArtraeat of Pc^rra colour
iv/rjirl C. P feiffer, Dir ector
Si&m&ry of Receipts end Fapeaditure 5 for_
t he period .Tune 1 , 1958 ihtou £ h j jay„ 3 It.A 9 i 2
Balance on hand 5 * 31“58 ■ Q
Recoiv£& f rooi Gcschictcter Fusi s.y?o
Direct Expenditures: 8 g 0>
Personnel _ 7^poo
Fellovships ,”„o'
Hunan Subjects • '-JL,
m rAVA ^ l^l *
Expendable Supplies . i /A gr
Total Di r ec t Expenditure s 9
Contribution to Indirect Cost . . 3 >>iP.
* Total Expend itures .
Overdraft as of 5 - 31-59 .
(TO be absorbed by E’sory University)
4,>7.8_..l8
S 51 . 465.00
( $ 1,106.02)
Overdraft
* See attached schedules
APPROVED:
PrTCarl C. Ffei'frtr', M. D.
Project Director
E)’DRY UNIVERSITY
y*
7 •
-r -**-.« A-.-W
- rjjf . J
* Ralph C . Divis-
Chief Accountant
I have c> .rir.:3 tr.2 n:.;rcv'd ito t *'' 1
eipcr.ictu: cs. ^
f\
Chief
;Z5JQ:.tzi:zl 3iv*-s:c:
pLle a yu
o
o
FJ'DRY UNIVERSITY
Department of Pharmacology
Dr. Carl C. Pfeiffer, Dir e ctor —
PERSONNEL
Position
Amount
Research Professor
.$ 2, 400.00
Secretary
875-00
Research Assistant
3,975-00
Assistant Professor
7,916. 6)
Instructor
300.00
Technician Specialist
75.00
Research Assistant
1,200.00
Research Technician
60O.00
Assistant Professor
225.00
Consultant
2,025.00
Visiting Associate Professor
2,100.00
Student Assistant
526.50
Student Assistant
l,*?? .75
Student Assistant
765.85
Social Security
387.26
Annuity -Dr,
11.16
Total Personnel
$24,680.12
FEU ON SHIPS
Fellow
Fellow
F ello w
Fellow
$ 300.00
300.00
3,300.00
.3,3 00-00
Total Fellowships
$ 7 , 200.00
Kui.an Subjects
$g,OT6.00
I h^vo tni arr-cv'd the submitted
c-y.pt-r.dila.cj.
7SS/C:.t--!cal Division
Bates; /i f s' f
Date
9/16-18/58
12/2-3/58
4/12-17/59
4/14-17/59
4/12-18/59
In dividual Destination
Dr. Carl C f Pfeiffer Princeton, N. J.
Total Travel
CK.No.
Amount
62011
$ 130,84
66569
77.20
73940
176.32
73912
180.00
SJ-4-22
— 142.65
Ij^-oi
o
o
FJ'DRY UNIVERSITY y 1
Dep artment of Pharm a cology
* H
Dr. Carl C. Pfeiffer. Director
EQUIPM E NT
ITEM
AMOUNT
Freight .
Hot Plates
Electric Clock ™
Freight
Dynartoster recorder
Carton Office Machinery
Freight |
Aerograph vith accessories
Freight
Freight
Electroencepralograph with accessories
Metal Cabinet
Service charge •
Semimicro polarineter tube
Thericistemp TeletheTmoineter
Jntegrateur Electronioue, Scientific Apparatus
Intergrater for Electroneplialograph
Freight
Total Equip".ent
UA • W
10.82
5'-43
776.78
29.10
20.50
827.86
29.43
16.54
6,242.83
4.19
25.00
30.90
91-67
312.39
1,208.77
3^65,
^.. 9r7Q3-39.
*»y.
HS/Chcaical Division
Ef-DRY UNIVERSITY
7?- 31
Department of PbarcacoloRy
Dr . Carl C . Pfei ff er, Director
ITEM
AIDIJNT
ITEM .
Chemicals
$"U.33
Chemicals
Photo lab. vork
' 7.65
Vire
Freight
6,09
Bulbs
Cats
^ 6.00
Dry ice
Dogs
K 18.00
Chemicals
Freight
-5.27
Office supplies
Chemicals
10.14
Housekeeping supplies
Filter strips, pipettes
33.17
Cats & Postage
Celite
7-73
Misc. supplies
Animal food
39-14
Chemicals
Chemicals
20.19
Chemicals
Telephone bill
2.48
Dry ice
Misc. lab. supplies
10.42
Cats
Tubes •
62.30
Bulbs
Mainte nance supplies
20.38
Rabbits
Telephone bill
6.33
Chart taper
Misc. lab. supplies
18.38
Wire
Mi sc . lab . supplies
8.50
Maintenance supplies
Electrodes & vire
41.94
Dogs
Yeast
4.04
Pharmaceutical supplies
Hydrogen sulfide
3.33
Radiodinated albunin
Chemicals
21.16
Electric supplies
Infared spectias
9-00
B65k ::: ::::t
Cats
37-00
Dry, ice „
Binding of Journals
31.05
Infrased spectres
Mice
36.78
Hearing aid cares
Pharmaceutical supplies
7.00
Tubing & vare
Cats
10. (X)
Book
Tubes
12.21
Book
Chemicals
55-86
Cats
Reprints
24.10
Telegram
Chemicals
37.56
Publiching costs
Dry ice
25.40
Chemicals ^
Cats
16.00
Book
Animal food v
68.50
Dry ice
Chemicals
12.91
Dogs
Dry ice
20.49
Pharmaceutical supplies
Cats
25.00
Rabbits
Telephone bill
4.62
Reprints
Book
14.84-
Reddle value
Tape dispensers
6.86
Vais
Cats & Mdse, lab. supplies
26.54
Misc, supplies
Chemicals
3.76
Chemicals
Book
5.39
Slice rule
Book
17-32
Lamp & connectors
Mice - lav;-
* - 63.79 •
• Shernoneters
Continued infect' colurtn.
-
Continued
A
Date!
AMOUNT
62.71
11.80
9*2 7
8.32
15.20
8.26
1.38
9 . 66
37-91
25.39
10.30
22.54
10.50
6.18
24.72
247.20
40.14
4.52
36.00
.48
18.44
14.94
11.59
15.33
9.00
8.14
17.37
35.06
4.78
36.50
3.00
33.60
8.29
7.61
33.98
27.OO
1.41
41.20
19.32
14.79
21,63
. 5»?5
20.43
6.13
28.17
. 12-63
✓jr 3
mmmm
n
O
EMORY UNIVERSITY
3
ITEM
AIDUNT
Dade transaminase
III sc. lab. supplies
Reprints
Dry ice
Chemicals/ tubing
Pharmaceutical supplies
Books
Chemicals
Mi sc. supplies
Want -ad charges
Reprints
Book
Election tubes
Animal food
Photographic service
Telephone bill
Chemicals
Photographic service
Total
$ 25.75
8.36
35. M
16.42
16.32
12.96
37.28
6.59
.86
5*4p
26.47
13.17
31.13
10.18
36.00
4.70
36.81
3j^0
$27M8.iq
<
#
1 It vt e:
oxj.-.nci - :
’ the submit led
ft
iZS/Ctczical Division
rate*- /jr
V? - 1 °
receipt
Receipt 1. !..««* acXoowle^ »< - »•*«•-«•» «« t ' , " k * !
^<,cU.Ch t «k|K^OW«,.
$4&, 378?00, payable to the^ESS^sS^^ 3 ^
„ lir> ,,„ A dated 3 September 195 fT^'* WQ ott
Ca ^er^ h g *« tbe amount of ^ ^
^ $M> 35 . 12 . payable- to; the
.tfc-./Y^ - _ m^r- __ .. a
iss^fE
Date:
/£>&/$
■“.•I' ■'(’*•''' 7
24 August 1959
H ? ~ H/
MEMORANDUM FOR! CHIEF. FINANCE DIVISION
VIA * TSS/Budpt Officer
SUBJECT '» ! MKULTRA, Subproject 47, Invoice f 10
•V Allotment 9-2502-75-901
1 , Invoice #10 covering the above subpr oject Is attached.
Payment should be made as follows:
Ca shle r ' s check la the amount
oa
of $48, 378. 00, drawn
^ Cashier's check la the amount of $1,935.12, drawn
Each check should be made pay able to th
S
2. Please forward the check to Chief, TSS/Chemlcal Division
through TSS /Budget Officer by 4 September 1959. s
3 . This Is a final Invoice. However, since It Is anticipated
that additional funds ■will be obligated for this project, the files
should not be closed.
4
*■*
A
Chief *
TSS/Ch emlcal Division
Attachment:
Involco 8c Certifications
Distribution:
Orlg 2c 2 - Addressee
1 - TSS /FAS B
yZ- TSS/CD
TSS/ CD if
ft
etraiit
INVOICE
For Service*
$50,313.12
V CERTIFICATIONS
ni It ia hereby certified that this U Invoice flO applying to Sob- ^
project 47 of MKUI/TRA, that performance U .atiafactory, t a C€
are being* accomplished in accordance wltbrnutoal agr, ^
detailed agenda of the payment, and receipt. 1. on r f
fhit bill I* just and correct and that payment thereof ha. not yet be
Chief, TSSVchemlcal Division
Date:
121 It I. hereby certined that thl. Invoice applle. to Subproject
nl. 41 of MKULTRA >*hlch «a. doly approved, and that the j
i. belnV carried out in accordance with the memorandum of 13 April 19
Ki DC« t. Ih. M>/A. Ik. •« <»>. ««■»'«* '•
memoranda.- ■
R eiearch Director
Date:
covcrlag the abora robprojfcct Is attached.
v-V; Payment should bo made its follows: ,. •' ■. . ■ ’• .v^-V? ■/*••: .i .-• .’
■./ #;r * ^ ^ l ^ v *rf- ■*• v 7 * . -• * ,-• . t » » yy.. ■ ■. ' ;
!^C> : ^vV£ Cashier** checK in the Amount of $>30, 740. 00 Cram on a * .- A
»S£l
Cj> ^^ 3_ fih<y.ald bn a^g payable to the
J ’ sSS ^&sas«e^^la
i
< • /•
•**«►* Please forward tho chocks to Chief, TSD/Res e-arch Branch . *-V-,
3«- » 3 a unal invoice. Kowcvor, etaco It Is anticipated
that additional funds vill bo obligated for this project# the files \
should not bo cl oood. •;',. /'• ' „• •.....*: %-• . ..:
Distribution: .' .
, Orlj It 2 - Ad drcacej
•\ — - — i- TSD/FASS
- • • , 2 - TSD/RB
TSD/RB<i^^r v ■ ' .•! \'-r • V < •; f ':>.; c T ^
5
•v. .
I • « " ’ •
y?-- y *
25 June l?S9
MEMORANDUM FOR! COMPTROLLER
ATTENTION l Finance Division
SUBJECT : MKULTRA, Subproject 47, Additional
'» Authorlratloa No. 7
Under the authority granted In therneraorandum dated
IJ April 1953 from the DCI to the DD/A, and the extension of thli
authority In subsequent "memoranda. Subproject 47 has been
approved and $S0, 313712 of the over-all MKULTRA project funds
has been obligated to cover the subproject expenses. This
obligation of funds should be charged to Allotment 9-2502-75-902.
Chief
, TSS/Chemlcal Division
APPROVED FOR OBLIGATION
OF FUNDS
A
Research Director
Data: 3 0 JUti 1953
Distribution!
Orlg t< 2 - Addrei see
IXTSS/OC
TSS/KASB
2 - TSS/CD
ao7Hosi;i NG omc^~~
V'irW.
!f\~‘2‘.2* ' : PI<sa 9 * forward the cl
ifc through TSS/Budget Officer by A
chock to Chief, TSS/Chexnleal DIvisloa
lfIon**\£V
J . V"* -
. . ' - lavolce lc Certifies tloo*
.• Distribution:
' - \ • . v • ••*•/' .
:» E-'.S'.’Arf^^A.J: ;£■>.- 7*: • •?.>-• • -W. .- . • ■ . . • *
- I
MEMORANDUM FOR: THE RECORD
SUBJECT . : MKULTRA, Subproject 47
1. The. ’purpose of this subproject is to provide funds for
the continuation of the program being carried out at Emory Univer-
sity under Carl C. Pfeiffer, M.D. The scope of this work basically
covers the develo pment Tod testing of new c hemical compounds which
are hallucinogenic or otherwise affect the central nervous system of
hurnans. Certain phasfes of other problems of interest to TSS/CD will
be investigated.
2. The nature of the investig ations to be carried out under the
direction of Dr. Pfeiffer encompasses the synthesis, pharmacology
and pertinent biochemistry of potential hallucinogenic chemical com-
pounds. Testing and evaluation will be conducted in normal human
volunteers.
3. The funds for this project will be transferred using the
a-cut-out.- - — —
4. The cost of this program for a period of one year beginning
1 June 1959 will not exceed 378. 00. To this sum must be added
noupa
137 475
by n;jfijl?rity of; *37475 V»_ '
€?.-.$/ Ju'r.o 10/7 £
r*:
2 - ^
E2
$1,935.12 representing a 4% service charge to the!
HyA^-Md
making the total amount $50,313.12.
Charges should be made against Allotment 9-2502-75-902.
5 requested Emory University
to submit to the'in a summary accounting on an annual basis of all
monies received from the Also, it has been requested that
any unexpended funds be returned as soon as possible upon the close
of the grant year.
6. The requirement for a six months' informal accounting
on the part of the principal investigator is waived.
Title to any permanent equipment purchased by funds
granted the University shall be retained by the University in lieu
of high overhead rates.
8. In connection with travel under this project, it is agreed
that the Agency will^accept th^travel documentation and accounting
which conform with the practices of the University.
9. It is agreed that technical reports reflecting the progress
of the research program shall be submitted at mutually acceptable
intervals,
r
PROPOSED RESEARCH BUDGET
June 1, 1959 to May 31, 1960
for Grant to Emory University by
the
V?"i«
PROJECT A.' The synthesis and drug enzymology of possible
$8300.00
4380.00
USPHS Grant
Equipment
Travel
Consumable Supplies
Indirect cost ^-10% :
2000.00
500.00
2500.00
$17,680.00
1. 7 68.00
$19,448.00
R0JECT B. The Testing In normal human volunteers and the
pharmacology of Experimental hallucinogens,
Carl C. Pfuiffer7 Ph.D.M.DTrPrlncIpie Investigator
Personnel - .
Carl C. Pfeiffer, Fh.D.M. DTT^par t^t ift e)
O
J! t ip e n_ds_ £ or- huma n' volun t e e r s
Summer Student Fellows (3 at $600 each)
$3000.00
3000.00
3000.00
3000.00
1800.00
4P00.00
500.00
Equipment
Consumable Supplies
Travel
Indirect cost - 10X
4000.00
3000.00
. 1000 .00
$26, 300 . 00
2.630.00
$28,930.00
Total of both projects - $48,378.00
I
o r
u /? -fO
PR OPOSED R ESE ARCH BUDGET
Personnel, including volunteers $30,980.00
Supplies and materiel 11« 500.00
Travel It 500,00
43 , 980 . 00
Indirect Cost - 10% 4,398.00
Total $48,378.00
Carl C. Pfeiffer
f
^ * •
%
For Services
V
moica
sr.i ■
$33>?0.06.
QBKnFICAncm
■'I
(1) It Is hereby certified that this is Invoice #9 applying to Sub-
project kj of KCULTRi, that perforcencs is aatiefactory, that services
are being accoapllahcd in accordance vlth outual agreeoents, that a
detailed agenda of the payuenta and receipts is on file In 5SS/CD, that
this hill is Just end correct end that payoeat thereof has not yet been
code »
Chief, ISsTct^al cal Di vision
Da tel
(2) It is hereby certifie d t ha t xh.'s i n voice a pplies to Subproject
Ko. hj of KaULTRA. vMch vaa duly app roved f end that the proj ect is bein g
carried out in accordance vlth the curore.ndur of 13 April 1953 from the
ICt to the W/Aj end the extension of this authority in sulr-e^ent
cesoranda.
tririr:’ 5'.— J '»
*9
JUH
H'J
Research Director
1
Date*
■ r
EixiY uyiYEasm
v? -o
5@®l
&£^r*art
Peparte eat of Fbarracolocv
pr, Carl C, Pfeiffer. Director.
Susaiiy of Receipts and Expendlkires for
tha Dftrlod tTisv) 1,
iHy_^JL^2
Bai&oce oa head £-31-53
Fr.-eeiYoA froa
. 3
l9>3-59
Direct Expenditures!
Pereonacl
Fellowships "
Rusaa Subjects
travel
Bjalpeeat .
QcpeaiCelc Supplies
Total Direct goccail tvccs
Cor.stributioa to Xoiirect Cost
Total Expenditures
Overdraft as of £-31-59
1 (To be absorbed by Eneiy
$ £^$30.12
7,200.00
: 2 ;xxj 8 , oo
707*0).
9,703.39
g, 318.30
Unive rsit y)
* See attached schedule a
AKSOVTEBi
Dr. Carl C. FfelTfer r fiU 0.
reject Director * ^
r-d -31 umvrRsurr :
?
' m . * \
/' / *; '■ ‘ i
' Ralph C. Davis r*
Chlef Accountant -
I lave ex&zlr.:d end e;p:svti the submitted
expc- r.dlturccv
EJD3Y UKIYlSRSXTir
M3rOnt
Dr. Cat I C. FYeirt-er!, P irgstgr
H? - S"3
Fositloa
As<rm%
P.e search Prof c bdo r
Secretary
Reecarch AbbIb taat
Aislet-ent Professor
Instructor
Technl cl&a Specialis t ;
Reseoxeb Assist-e-nt
Pceecrch Technician
Assistant Profcscor
Contultent
Yieitins Aeeoctet© Professor
Student As si stent
Student Assietaat
Student Aoslet&nt
See led Security =
Annuity-Dr C-
t
TotaV. Personnel
fcs!i,e80.12_
p r- n- firr£Xtil -**
y n.I0VSSIP3
FcUcrtl
feUcm
Pellof
Fellov
Total Pc nov sh ips
fc 300.00
3OO.OO
3,300.00
fc 7.SCO.00
Bvoaa Subjects
fg. q< 8. co
I have exanir.cd end approved the spitted
expenditures. .
® Chief
ISS/ChezicEl Divirion
Date: 1
r
V ? -
O
BOfnf usiYEBsrrr
Date Individual •
9/16-18/53 to. Carl C. Pfeiffer
4/12-18/5$ '
tostinatloa ___ ■
Prin 6 st- 0 a # if. J.
n ?<t- 1
Total Travel
Ctf.fo.
Aaouut
62077 $ 130.84
'66569
73910
13912
8 J-V-22
1 lave examined and approved tbc submitted
expenditure 5.
c..ic-f
TrS/Cbv-lcal Eivliloa
Bates u' )!<v j '»»v4* v ‘7i>f
V Carl C. P feiffer, Dir ector
E QUIPMSSt
Freight .. • . •
Eat Plates ' '
Electric Cleclc ^
Freight ' . • . . . ■
Pyrkancster recorder
Carton Off ice Machinery - ■
Freight
Aerograph vltto acceB&or lea
Freight '
ElecSocDcepralograph vlth acceeeorles
Ifctal Cabinet ; ‘ •
Service charge . .
SenlaicrO polarl'-tclar tu be
Theroietcap Telcthemavc^r Apparatus
Integrate ElectronJ^uc, APP®-
Intergrater for Flee trcmeplialograph
Freight *
t£ML
5.73
61.80
AO. 82
5'.43\
776.78
29.10
20.50
827.86
2 9.43
16.54
6.242.83
4.19
25.00
30.90
91.67
p.2.39
1.208.77
Tot-al E^ilp^Dt $_ £r7Q3.*3i
I Have aga.-.ir.vd and approved the sjh.titte;
expendit-r*s.
J&£> * *
StSI!
.‘TSS, C'r.er: :si I-T'rloa
Pater ^3^
►'. .■v. v.A «.«- * /> /
V. - ■ * .. ' >' -». - J- - ' L ■-.- V - 1 ■ 1 1
C I I " -O
£
1
£U>KY UNIVERSITY g
I
Danar leant of Bvm ideology
Dr. Carl C, Pfeiffer. Director >
• -- • —- • * - - • • * o
n
A1PU? ft - I'fKX |
| 11,33 ' Chemical* c
7.65 Virs * '
6.09 Bulb* o
* 6.00 Dry ICO 5r
S 18.00 Chemicals o n
.5,27 Office supplies ;®|
10. 14 Housekeeping supplies^
33.17 Cats & Postags ||
7*73 lii.se* supplies rrx -
39.14 - Chemicals --
£ 0,19 Chemical s
2,48 Dry ice
10.42 Oats •
62.30 Bulbs
£0.33 RabMta
6.33 Chart paper
18.38 Wire f
' 8,50 Maintenance supp lie s
41.943
. 4,04 Phanoaceutical supplies
3.33 Radlodinatcd nlbiriln
21,l6 Electric supplies
9.00 Book
37.00 Dry ice .1,
31.05 Inf leased , sp ec tras
36,75 Hearing eld.. ceres
7*00 Tubing & vare ;
10700 Boob IT 35.06
12 . 11 *. Pools 4.78
Cats 36,50
Tele gran 3.00
37.56 Publiching costs 33.60
25.4o Cbealcels 8,29
16.00 Boo k • 7.61
68,50 Dry ics 33,98
12.91 Cogs 27,00
20.49 PharreceuticaS, supplies 1,41
25.00 Rabbits 4 1,20
4.62 Reprints 10.32
14.84 Kcddle value 14*79
6,86 v&is ’* i&rtj
26.54 Mice, supplies 75*25
3*76 Chemical* 26,43
5,39 Slide rule • 6.13
17.32 7 le^ li connectors 28,17
63.79 Tticrcccjcters \ 13 ,63
CoatBoued- P5 page 2
r
3
C
O
O
rvi ^
K
Cheaicals
Kioto lab, vork
Frei^it
Cats
Dogs
Freight
Cbeolcals
Filter strips, pipettes
Celite
Aninal food
Chemicals
Telei'hai? blU
Klee* lab. supplies
Tubes
Jkintenarce supplies
Telephone b ill
Kisc. leb. supplies
Kisc* lab. supplies
Electrodes & vire
Yeast
Hydrogen sulfide
Ch'- deals
Infared epectr&s
Cats
Binding of Jo urnals
Mice
PliSLi-rjeccutlcal supplies
Cats
Tubes
Che.nl cals
Reprints
Chemicals
Dry ics
Cats
Aninal food *
Chemicals
Dry ice
Cats
TelepM a biH
Book
Tape dispensers
Cats & Hite. lab. supplies
Checvicals
Book
Took
nice
Continued next col\/nn
a Vs vi '
O o * .
■q^ AiPUST
62.71
11.80
9.27
8.32
15.20
8.26
^ 1.38
8 9.66
S 37.91
« 25,39
10.&0
22,54
10.50
6.18
24.72
2V/.20
40. 14
4,52
36.00
,48
18,44
.14.94
' 11*59
15.33
9.00
8.14
17.37
;
\
% >
*5»3Y IClIYKRSmf
Ps ^sytceat of Ptercacoloa r, .
P r« Carl.C. Pf eiff er^ Di rector
Issi - * - AMXQTf * ■ '
Ihde transastnaae
MUc. lab. applies
Reprints *’
Dry ice £
Gtecdcals, tubing . 5 ; *
pim'aace'jtical supplies
Books
Chemicals
Mi&e. applies
Vant-ed charges
Reprints
Book .
Election tubes
Antral food
Photographic service
Telephone bill
Chemicals
Footographic cert ice
Total
*
8.36
35.V8
i6,te
16.32:
12.96
37.23
6.59
.86
26.1*7
13.17
31.13
10.18
36.00
V»70
35.81
«ssH
V? - o
Data r <s ', lf v-*'r-vU*v- I 9 5 j?
ussoarntM rmi cmr, nmucs
* '% <' T
SO July 195°
ecSJEOJ ;J : |* J*an/CWr'6t*yro3««t kl. Invoice Hp. 8, ;
It is r©<juoetcd that payo^at be cede as follovsi
*. V oo
‘ •** - •V. ' * / -
:*•% — v. •;. t ; . .. ^ _•. € . * •; * .. • $.* \j. ;v^y,v . -•-•-rVrv
* . -V* • ; \ " . • . ' ‘* "• * ' *"■'-* 'iW ; j -■'■'>* /"'"*! -
for " :.. ■*?■•■
'■: ■• • :SC r- Z : -:V'^ vv,J
-—.-V' ' '* * ,ji v - " : : "*v;hj:^:_^l.";-: * * : ‘*'» ***
^• : '2. ' 5fcs' chsdtfl-'chould f^S^ded to'Chicf, H6a/Cmic»\ *.:. •• .
Division, through KS/Budcai Officer, no later than Wednesday, ' ; v ,; : •;->*.>.
/b
Attechseotai
.Invoice Q&**** £
Dlgtributiaat '.’■ ••■> ^^IVEOi avg ' ■ ' "
<**« 6 -‘ •■'-■ • .■+•■ - : ■ ._
iK@
■» CV • * ..* »■ . * . . ■ -- TOXlFlIIir* . -
- •• •• ■ • . VSWV _ ft jQ *
grg ' : co'M7S. '&&;£, '/*•*• y*mc.&'
• ■ * ‘ . ■" • — *. " ‘ 1 1 ~l . ' ‘ '
2w. i-j>~
'R>’R0
”; v> T-; ;T
■Z\ *7 **UW 3 tA vhlch V 39 duly approved, aod that the project i a he leg • >t» ;-j&?
r; ' v' V>^^- carried out in accoPdanco..vith -tho laerwanduo dated 13 -AwJ.l 1953 .?•.'>*.•
• .v iixiithe MI to tho kd/a. fit* i%V+^n«lAti «* l« m.V- * *
' * - *> : ' V » ,*v. ; . .? * • .• .'• .* .- ' • v\ v : v * • " ■ •• ■
; ; ■• ... , *.• • «• . .
. . ■*'* . m \ **•.*•• r * - •* ‘ * • *• j* * * . . -•*- * * -
"'Or ^ ***■ .
•. “
by O'J
date
E2 II
MNFOTIfl ■
7475 f »
,1
r**
DRAFT
19 June 1958
MEMOSAMTXJH FOR; THE RECORD 7
SUBJECT : KKULTRA, Subproject 47 —
1. The purpose of this subproject is to provide funds
for the continuation oflthe program being carried out at Emory
University under Dr. Carl C. Pfeiffer. The scope of this vork
is outlined In the attached pro posal submitted to D rs . Pfeiffer
r n 1 "Ulifflit sad basically covers the development and testing of
new he-lluc inogenic compounds as veil as certain phases of other
problems of interest to TSS/CD.
2. It should be noted that es in past years, a consider-
able portion of the total cost of the indicated program vill be
borne by agencies other than TSS/CD. These include the U.S. Public
Health Service, Emory University, and others,
^ 3* The funds for this project will be transferred using
usual manner. r?
4. The cost of this program for a period of one year, be-
ginning 1 June 1958 vill hot exceed 202. 00, to vhich must be
added the fair percent (4j6) fee to the "SaV.ing
the total amount $50,130.08. Charges should be made against
Allotment 8-2502-10-001.
CSS I?.
; CCiiFIDtlSfAl '
f : 187475
77 1
V478
>has requested Emory University to
frity
O - 2
. '■ '■ ’• aTsirST'"'
C
E2 1 t^^S^t'heca a summary accounting' on an annual basis of all monies
i
i
i
\ ~
i -
i
t
!
j
i
r
i
received from the Fund. Also, it has "been requested that any unex-
pended funds ha returned as soon as possible upon the close of the
grant year.
6, The requirement for a six months' informal accounting
on the part of the principal investigator is waived,
J. Title "to any permanent equlj>ment purchased by funds granted
• a
the University shall he retained bjTthe University in lieu of higher
overhead rates; -
8. In connection vith travel under this project, It is
agreed that the Agency vi 11 accept the travel documentation and
accounting which conform with the practices of the University.
9. It is agreed that technical reports reflecting the progress
of the research program shall be submitted at mutually acceptable
Intervals.
10. Dr. Pfeiffer has signed the Memorandum of Agreement
and holds a TOP SECRET Agency Security Approval.
TSS/cbemical Division
fit
APPROVED FOR OBLIGATION OF FUNDS:
1
/tiUt
Attachment:
Proposal
Distribution:
Original only
ilLV-V^v^
-5-
rN C
'• ■ PROPOSED RESEARCH FOR 1358-53
4 ^ -
,. CMtim . ^ .. -«-«• -~£.rr ha,,uc,n :;;;;;r ^
. • *a which become available fro™
cals which have been synthesized by .
- has 30 chemicals awaiting testing in -»«• C.
commercial laboratories. * • .
• , n/( ;fi. c the LSD-25 model psychosis
2 2 -di«th,la»inoetha„ol ■« pr.tt.In>ry tr.als -
in .r . W .~ H «*- - '» - : ; ;:- •
haIluciMti o„ s %*-. a **.. «>- *-* » f d “ i9n “ ,n i *
• *
set up to quantify this effect.
* of 2 -dime thy l ami noethanol in natural foods will be deter-
3 . The possible occurrence of 2 dimethyia
-„,„ed b, steam distillation and paper cbrcm.t 09 r.ph,.
• • aft H its tertiary amine derivative to ascertain its
II. Jests will be made on Carn.t.oe and its Y
possible role as a neurohumor m the central nervous y
5 . T he D and L formS of lactylchol ine have been synthesized and will be extensive -
tested in animals to ascertain the possible 'similarity to ecetylehol me. t er
. . -n he esterified to choline to determine
natural occurring alpha hydroxy acids will
their potency.
. • ,1c of those compounds which may be submitted
6. Continued testing in ... .nd .n,.als of those «*p
by on d-aminoxidase activity
7 . Determination of the etlect ot c
in vitro.
QUO
a\.ia>«£.45. Ms-iesisE?.
-y^- — £
* 19 Juna 1?5S
K3403ANIXM PORt CCKrTROLLSR
ATTiClvriOtf I Finaoc* DlvieiOQ
SUBJSCf I . KdTC/TRA, Subproject Vf, Additional
Authoritatico IR>« 6
Voder the authority g reated in tho noaor finAu* dated
13 April 1953, frca the KX to tbs K)/A wd tba extension
of this authority in auhsoqueut c^v^iWIa, Subproject *»7 ^
veo previously appro ved t Vader the aaaa a ut hori ty M id* :
<5 1 tt oral eat of $^>0, 130.03 haa beoa authorlted to cover the
eubproject** expeaoea (thoroty Vrin^tng to a tot^l of ^5^il3^»03
fuMa oblicatc4 during if 5-0 ) to to dergcd to A lioto>nt
&- 2 yje-io-ooi.
*»'••**<
ATPRCYSD FOa OBLIGATI C« O? FUlvDSi
R&eearch Director
Date*
DistriVutloal
Ci te A 2 - Addrcasoe
1 - TSS/CC
Kx - T3G/fASB
1 - TSS/SKB
2 - TSS/CD
Chief
TSS/Cbcaiced Division
lc -r-ET,^rv ; r 5 ^AVA.VAiu ( ' 4 #
c,./.; -i JO « c- -•* — -
sMDWf uanis« 1Tt
'^ KsS ^ sU ^ a 5 ^®-
„ , c Ff affex ^^ lrC ' C — x
^ pr. g&r 1 C t ^ :: r rt.
%
• ' ... for theJSli ^
« U pod gx^P.dA^-- 8
Jane S - j l 3 *
^ uai . oo ^
i 22 , 695 -^-
6 . 000.00
3 , W .00
1 , 135^5
Vf^-£
•towi Ex ^^«*
0M ^.i “ ot 5-3 ’
$ H 2 , 058.|0
3l^-—
^ 20^02
$J31^
■ Co xTc. »Uf«r. X^K
Reject Dirccior
itfOR* USlYEKSITt .
- --■ - 0 . ?• A *
Ear > KU ; U
Chief Acc0 ' 13t ^
mo ay university
Grant
De partecat of Fhargacolo^y
Dr. Carl C. FfelTfer, Director
H 7- -b f
2 .
PERSONNEL
PoSltlOQ -
Student Assistant
Re search Ass Is tent
Research Assistant
Research As sis taut
Ass i st an t Profe ssor
Technician
Re s earch Te elm l c len
lah^KSia: r
Student Assistant
Student Assistant
Student AsMstarit^!!!
Re search As s Is teat
Technician
Asst. Professor
Ins t ru c tor
Technician Sjeclallit
Student Assistant
Graduate Assistant’
Instructor
Social Security
Total Personnel! ^
Araount
$ 100.00
525.00
600.00
3,000,00
1,083.32
750.00
275.00
181.00
06.15
969.2k
1.327.00
500.00
3, >75 -00
7.125.00
703.32
225*00
100700!
22.50
15.00
. >
fellowships
Pc 1 lev
Pellcnr
Felloir :
Total Fellovshlpf
| 600.00
2,700.00
2,7 00.00
$6,000.00
husan Subject*'
r
H7-Z1
mom uiuykksity
2)
Departoeat of Phara acology
M
Dr. Xarl C. Pfeiffer, Director—.
TRAVEL
Date
6/28-30/57
8/23-30/57
e/23-25/57
5/3-7/57
c— 5/3-10/57
12/5-6/57
l/2«i -27/53
fc/ll-18/58
Individual
Destination
Dr. Carl C.^Pfelffer Chicago-
Dr. Carl C. Pfeiffer
Ck.Ko T
3876V
Arount
4 71.26
Dr. Carl C. Pfeiffer -Vashin&toB,D.C;
”51237 iio.96
SJ-8-1U7 35.37
5 18 55 25s . 61
51883 65.60
Dr. Carl C. Pfeiffer VeJshi«stoa,D.C. 563/0
Dr. Carl C. Pfc lffor »Kev York Cit y 1
Middle too/ Conn .
Dr. Carl C. Pfeiffer Chicago and-
FhiladelphiA
59571
S5262
103.10
I83.7O
IL135.-M
Total Travel
v? - s'?
KX PENMBLS SUPPLIES ("
ekory iwivKR3iTr a
V?
Grant
Department of Phar-Bacology
Dr. Carl C. Pfeiffer. Director
Dog#
Chemical determination*
Batteries '»
Data sheet# . ■*
Data pad#
Thermometer*
Chemical*
Diffusion unit
Chemical*
Manual
Mica
Chemical#, glaasvare
Cat#, postage
Chemical*
Culture
Chemical#
Alcohol
Chemical*
Spatalos, chemical*
Cat#, lab. supplies
Cat#, lab. supplies
Bottles, tubing adapter
Antral food
Chemical*
Aninal food
Chemical*
AnJ ral food
Cat*
Chemical determination*
Freight
Chemicals
Tube*
Bcseerch notebooks
Be co id supplies
Melting point apparatus
Wire, tubing
Cat#, postage, rise . supplies
Fharm&cert leal supplies _
Chemical analyst#
Pipettes, acetone, ligro in*
Stainless steel ej<atula#
Chemical#
Aniral food
Bther
Photographic service
Continued next coium
AMOUNT ITEM
*
36.00 Kyrograjh paper
3.09 Chemical#
8.33 Chemicals
19.83 Scotch tape :
45.32 Mise, lab. supplies...
31.63 Ch emical#
21.75 Chemicals
91.96 Keedles, valve, stopcocks,
5,75 c’her. i cal*
I .55 Chemical*
60.97 Ga* (02)
44.20 Aniral food, e&d&r shavings
39.48 Photographic vork
46 , 83 ^ 7 ^ CheMcal determination*
4.47 Mlsc. lab. supplic*
3,31 ; Preference look
6.41 JReMlr postoid ronguers
2 . 66 An inn l fo od :
34.56 Chemical#
IS. Co Plyvood
34.46 Regulator'
!*i.5l Thermometer*
42.16 R eprint*
5.83 Alcohol
43,78 Pharnaceutical supplies
19*3? Chemical#
13.39 Reference book, slides
24.00 Chemical*
41.00 Thenroroter#, chemical*
4.37 Off ice sup plies
19.57 Table cart
31.91 Alcohol
119 . 58 PtaJiaceutical supplic#
29.25 . Chemical*
21.73 Reprint#
19*37 Reduction gear
38 . 9 1 Che ri cal#
24.50 Freight
6.65 Mice .
84.91 Keedle#
24.00 Slides.
I 55 . 5 O Pork liver
26,27 Sturditlp*
17.33 Chemicals, tubing, # topper#
23.10 Magnifier
Continued to Page 2
EXPENDABLE SUPPUKS
AMOUNT
? - Tt
Forvari from Page 1
Drugs • 4 15*97
Electric Motor 8.76
Miec. IaTj. supplies 37*84
Chemical 8 . 19«60
Apron, flasks, tubes 35*82
Bed herringbone toweling : ; n 9* 27
Stethoscope-head, tubing ' 13*39
Chedcal determinations 13*00
Svivel casters 9*02
Kullraatic pressure regulator 23.68
Plastic covers, cheat cal* 1J.44
Photographic vork 23*25
Ice torgs 11.21
Ether, funnels 11. 06
Freight 2.08
Office supplies 5.50
Tepe 1 .h4
Alcohol 3.85
Pharmaceutical supplies 8.00
Che deals 10767
Stoppers, grease, test tubes 19*03
Adapter 3*20
Chemicals 2.58^:
Casters 6.15.
Chemicals 6.56
Forceps, scalpel 9*21
Binding Journals 30.90
Reference Booh 6.5I
Chemicals 2.02
Forceps 1 6.96
Chemicals 11.17
Chemicals 1*1.20
Reprints 33*0077
Ml sc. lab. supplies 37*79
Chunicals ^ 20.81
Chemicals, flasks 14.20
Freight 2.30
Chemicals 8.55
Funnel 2.59
Chemicals 25.03
Polyak vertebrate visual
system 37*52
Chemical determinations 13*39
Freight 2.24
Chemicals 8.78
Funnels 5*^2
Helium, valve 18.47
Miscellaneous supplies 30.94
Cheaelcals 16.53
Freight 5.43
Chemicals 21. l6
Chemicals 4.64®
Chemical determinations 39*50
Alumaum foil, dispenser
Frogs .
Bottles
Magnetic bars :
Pl asti c cover
Vatch, glasses, chemicals
Stoppers ;
Chemicals
Flasks p chem icals
Drugs
Chemicals ;
Chemica ls :
Chemicals
Rep rints
Chemicals
Reprints
Chemicals
Office supplies
Ca te
Photographic service
Chemicals
Funnels
Ch emicals
Animal food
Freight
Animal food
Mis c. lab', supplies
: ^ : Total
».' 'I
4?
22 April 1958
- V caw/, DimICa •
H3KRMWM officur '
<JX • ,„ t l,t, l*,ol« So. 7.
Kft -7 . ccnrerios foUov*»
„ **.*»•* *•*
* .. „. d«-
00 “
~ o{ ^, 2Jl
.., ,er'> *&£ *& ^
I
i
vr ° Jcct '
: r; ' : -
JviECK^4i|l ‘ T #
RECE^^* rA
A
S &*1 B1>ulw
^fwt'c^ufi^ucc
Af'- ■KS/fASB
l o ._ tss/cd
-? r"i
- ^
. ,.t
. clW « ^‘ a r J* -J^rT/t ' fi
C*a/*'
'f'V' * J
For eerviee*
3 L. ,
133 , 571-90
- - - . *
;■ ce?fiincA.TXCf 3
'StVlXSi XJ^.f, £ «r£S S w»»t «*?»
,s/cD, «-»\ tJ ' u i ’” 1 11 0
fias not ^tto»-^.V::---.:.:: ::: .„
pivieloo
» t i9 j^re^y certified ^ 0l1 ®
^ tie LCI « tte PD/A, w* w
p^ocutunAft*
S%* T'tK
^>>1. 5te#
,, *! r .:^t,
(1) IS I» hereby certified that tbl« ia Invoice #$ applying to Subproject #4 '
of MKITLTRA, that performance. la^ ^ e alia factory, that aervlces are being - -
accomplished In accordance with mutual agreements, that a detailed agenda
of the payment* and receipts ia on file in TSS/CD, that thia bill la Juat and :
correct and that payment thereof baa net yet been made. ^ -v
^ KULTR A which waa duly approved, and that the project la bci
:s ?$Sr* V* l ' carried out in accordance with ths memorandum dated 13 April
... *: - r jV -1*’ • * frrtm thm nr*? *Um. nn/ a . .m . V ~ !„ ./m. L.,.i
mg
my
* ■. .i > v. \ _< “T , » *« . V»‘‘ " *••*.*.’ *!*“». r> *-
r-V- .'i\. *^7 r '-J* Y^^;- * * .i _ ■
; ■ ; -i ^ >r"; S ! Reiearch Director
o
C; U 7 -Oi
: }
EtOHf UNIVERSITY
2 >
Department of Pharos oology
Dr . Carl C . Pfeiffer, Director
gusnary of Receipts and Expenditures for the Period
^ae V. 10^6 through
Unexpended bsler.ce May 31 , 1956
Received fron this period
Total Funds available this pe riod
Direct Exp e nd! t.-tre s t ♦
Personnel
f/{l'3ipn subjects
Travel
Equlpaient
Expendable Supplies
Total Direct Expenditures
Contribution to Indirect Ccst
Total Expenditures
$23/^3 -75
3 . 493.00
1,933.50
5,563..7*»
4 , £ 37 . 97 ,
^,001.90 :
4 . 309.00
Credit Balance as of May 31 # 1957 tr< *. ^
(Bnory University v ill absorb this overdraft) . v ’ c< ^ ft?
$ 377*38
V f,403 .00 .
447 , 780*38
43,310.96
♦See attached schedules*
Approved 1
. <et C?/‘^
Ca r l C * Ffc-iffer, >^. D. /
Project Director
D ife,
1 D iV}
Ennry University*
h
Evell E. Bessent, C*
Controller
P. A.
KM 3 KY UNTVRRSITf
2 ?
y? - 01
Department of Fharnaoology
Dr, Carl C. Pfe iffer. Director
PERSONNEL
Position
Amount
-Pfeiffer, Carl C»
w
Research Assistant
Student Assistant :
Student Assistant
T . : Research Associate
Lab. Hi id
Instructor
. C. P rof e ssor
Student As sistant
Research Assistant
Technician
’ Secretary
Associate Professor
Technician
Technician
Instructor •
Student Assistant
jgjT Student Assistant
Technician
mPk Technician
Student Assistant
T.I.A.A. - Dr. C. C. Pfeiffer
Social Security ^ ^ ^
Total Personnel
$ l, 8 oo.
606 .
6oo.
6 , 599 .
1,856.
600.
750.
600.
2,4oo.
3,300,
2,125.
4,333*
1 , 485 -
137-
250.
5 &>.
156.
46.67
46.67
12.00
37-50
Hunan Subjects
!VG Ci-c? f
ei ? G nditur £ .;
^nc-d c.^ .
- t v, j^v.,
«V« Si>,-44 V, i
» Cft ief
ISS/c, --«> %^ 3I£s ,
tea
8 8 8 >5 8 S 88 888 8 > 5 $ 888
-w 5 *
/
s
r
'll-
y? -ti
B©RY UNIVERSITY
J3
Departrsent of pjanaacology
Dr. farl C. Pfeiffer. Director
Grant
travel
Date
6-29-56
IO-I-56
10 - 1 - 5 ^
10 - 23-55
10 - 25-56
11 - 27*56
II-27-56
}a-27-56
11-28-56
11 - 23-56
12- 27-5 6
3-27*57
*» -25-57
*» - 30-57
5-29-57
5-30-57
Individual
Da stlrvatloa
Dr. Carl C. Pfeiffer '
' ' -.y- vp^*
, ,_
French Licls, lad,
- •
•■ -Je ...?*£» • '•* r ?•• *«* . .
t . *?'V
Dr. Carl C. Pfeiffer
Dr, Carl C.FTeiffer
Dr. Carl C , Pfeiffer
-f-y - • *■ -
*r %v, « v ■»*-$*
• and Washir^^tOD, D. C. i
Cbic-aeO| 111,- ;
Amount
171.18
2.07
238.07
77-
157.
61 M
132.14:
263.69
38,46
154.52
135.15
97.06
164.67
112.81
Total Travel
r
c
E®RI UHIYERSIDf
Grant
Department of Fbanjacology
p r , ‘ r.Ai- 1 c. Pfeiffer, Dire ctor
QUlPrgNT
Itea
trip i*fl 8
Conversion Model thercODeterA
Dazor Lamp
Dry Ice storage cabinet
Desk
Chair
Stopcocks
Transcribing, dictating rachines _____
Stopcocks .
Strain Gauge arches . •
Respiration puap • • . „
Freight# customs on scientific apparatus
Grinder, sav 6 l/ 4 H sender
Freight
Telephone cabinet
Freight '
1 Sofa, leather ‘ : --~ ~ 773 ~ 77
Input couples for FEQ
Desk
Reinforcing desk top
One Model 1II-D laectroencephalo&reph
partial refund on typewriter reported last period
Total Equipment
Anount
1 X 47-66
76.88
16.67
* 123,09
50.99
36.42
14.84
334.75
3.04
108.15
395.66
142.71
185.92
10.45
67.10
4.91
309.OO
247.20
50.99
2.39
3 , 235*99
( h*0
res.
1 ^Ve c,; 2 >.
~* B * ^orc- %
/Q.
ff V — *»
° J ■ ' ss/ctei!c « i lvl8Jrm
f sioa
2S57
‘•JF J
»»Bf UTiIVKBSrnf
3
■ .in..* u-iuiijiii JfW'iJ!"
c
Grant*
Department of pbarnacolqgy
Dr. Carl C. Pfeiffer, Director
"/? ~ ^ Y
KXFKSMBLB SUPPLIES
Itea .?
Amount
Itea 7 7
Amount
Flasks $
4.79
Freight
$ 2.42
Chemicals
12.91
Gasket -
.55
Heaostats, Forceps
84.65
200 bars Ivory soap
945
Animal food
67.77
Dogs
305.00
Animal food
6.54
Telephone calls
8.47
Chemicals
9.43
Drugs
,-55
Telephone call
6.66
Postage, drugs, file
26.76
photographic vork
8i*^5
Freight
1.99
Chemicals
47*56
'• Thermometers _
14.13
Rubber tubing, cben&ical
“7 — ..• •• •
Knife blade
4.55
bottles
23,32
EKL rarer .
283.25
Desk
12.62
Pyrex stirrers
52.74
Platinum Oxide
3547
Bio of lab. muse, shell
6.38
Drugs
7.35
Design cards
2.2f
Magnets
21.09
Telegrsa
3.70:
Miltiplosic Personality
Book
10.17
inventory
24.21
Laundry
41.65
Tubing, adapters
7.85
Date pods
19.50
Office Supplies
21.51
Mice lab. supplies
15.66
Drugs
34.55
Telephone .calls :
5.01
Alcohol
1.71
Dogs
145.00
Dogs and cats
170.00
Book - reference
8.23
Postage, telegram, drugs
U0.73
100 nets! card holders — ~ -
15.49
MPI cards & recording sheets
38.73
Telephone call 1
2.09
Rats
66.38
Telephone call
12.82
Culture cape
Chemical 8
Insulators ^
Hypo needles, therrooetere
Bottles & chemicals
Klee
Dru^s
Mueller clips
Paper roller
Drugs
Dinge
Angle iron & costers
chemicals
Laundry
Gas h needle valve
plyvood
Photographic vork
Continued next column
9*79 7 jh Coats
65 . 06 fch or, i cal 8 , tubirvg, spoons
5*9
29.27
54.07
58.32
31.14
#<46
f.&S
31.52
3.12
40.15
18.03
31.72
22.56
85.64
4.00
Spoons'* •h’Jtf
frea&s
Hi^elS
12.02
50.33
24.^4
5.69
50.26
Freight „ 3.B8
30.00
/\ 826:68
^ 43.5?
8.54
/) ^ 7*56
Photographic vorK^k/,.,-^ / jjj, ^32.50
Cbei^C-al deteralnoaatlchs ** 0 21 ,63
Chemicals 391.82
Chceicals, flask* 20. 32
Chemicals 5»10
Chemicals, lab. coats 21.50
Balance forvard next page
Che:-icaVs‘i
Lnuniry Cjx/'Ji?
St-opcocky'ic^jfethe ''-S
Chemicals
24 May 1957
MEMORANDUM FORl COMPTROLLER
• ATTENTION i - Finance Dlrbloij
SUBJECT! MKULTftA, Subproject 47, Additional
Authorisation No, $
Under the authority granted In the memorandum dated
13 April 1953, from the DCl to the DD/A and the extension of thU
authority In subsequent memoranda. Subproject 47 was previously
approved. Under the same authority an additional sum of $50, 357.84
has been authorised to cover the subproject's expenses (thereby
bringing to a totals $50, 357.84 funds obligated during FY 57).
to be charged to Allotment 7-2502-10-001.
SIDNEY GOTTLIEB
Chief
TSS/Cherhlcal Dlvtstoo
A PPROVED FOR OBLIGATION
OF FUNDS!
Research Director
Date! ,^29 1357
Distribution!
Orlg A 2 - Addresses
i - tss/oc 1
^"T'-TSS/FASB
1 - TSS/SRB
2 - TSS/CD
J '
TSS/CD:J^^sr (24 May 57)
ft
+ 1
J ^
£p <&
v, ¥"T C
c^c/j-V'fV _ -
iTiwsst: «■” 18,4,5
MEMORANDUM FOR: THE RECORD
r
draft/igss
24 May 1957
SUBJECT:
MKULTRA, Subproject 47
" 1. The purpose of thts subproject is to provide fun«3s for
the continuation of IWn^™ ^ing cSr^ied cut » En,ory Uel
versitY under Dr. Carl C. Pfeiffer. The scope of this work is
outlined in the attached proposal submitted by Drs. ^ e l er
c *if§PMnd basically covers the development and ^esUn go * '■
^ hallucinogenic compounds as well as certain phases P
lems of interest to TSS/CD,
2. It should be noted that as In past years, a considerable
portion ol the total cost of the indicated prog. ram Will be borne by ^
agencies tha. TSS/CD; y -
Service, Emory University, the^^^^^^*^^
3. The funds for this projSt»JU.be transferred using Ihe
— as cutout in the usual
manner,
4 The cost of this program Tor^a pejrjod of one year, be-^
• « /ittno i q sv will not exceed $48, 421.00 .to which must be added
ginning 1 June 1*5 1 will not e making the total
the four pe rC entJ4%) feeble maK 8
arnbunt($50, 357. 84
x ~— ft
a- -y*. ^ — « . .. . H ■ . J C'.v* TlrtluAPCitV
5 The «e#^gi^^^has requested Emory University
to submit to them a summary accounting on an annual basis of all
^es reclwed Troth th^ Fund . ^Isb, U Has
any unexpended funds be returned as soon as possi e upo
of the grant yean. r
6. The requirement for a six months informal accounting
on the part of the principal investigator is waived.
7 Title to any permanent equipment purchased by funds
granted the^ University .tall be retained by the University in lieu
of higher overhead rates.
8. In connection with travel under this project, it Is agreed
Ponn^ced to^/tC!dlDt!!TIAL
ty pxhorliyof: VS7475 s
date/ Jaeyl577 / /
T2 CL BY/ 18/475
h
8 !
3 -
I !
i :
by fi'ut
O
‘t)
MBS
f*
«y?— 4 7*
187475
that the Agency will accept the travel documentation and accounting
which conform with the practices of the University,
9. It Is agreed that technical reports reflecting the progress
of the research program shall be submitted at mutually acceptable
intervals.
10. Dr, Pfeiffer has signed the Memorandum -of Agreement
and holds a Top Secret Agency Security Approval.
v9
APPROVED FOR OBLIGATION
FOR OBLIGATION OF FUNDS
fSk
Chief; -Bj^nch'fl
TSS/ Che m i^LXJivisi on
Approved:
ReseSr£h Director
ChTe^~TSS 7 p^eroical^ Division s
Date:
1:31
Attached:
• Proposal
i
Distribution:
Original only
i
»
i
i
-V
Dovrrrn~i<3 l 0; ffit)
by eutbfsrlty of: 187475
cate: June 1^77 /
12 I *_*■ rf. ;■» Sr r r ^
I
' r • o ' : '■■ rr ~'~~~cT
/ PROPOSED RESEARCH PROJECTS FOR 1957-58
Human volunteers - Atlanta Federal Penitentiary
W- 0 ?
potentiation of LSD-25 psychosis with cortisone
2. Triais of new hallucinogenic agents ^
iDibenamine and Dibenzyl ine as antagonists to LSO-25 •
4. Search for new antagonists to LSD-25 ....
5. Trials of the so-called inactive isomer i-LSD-25 as a hallucinogen
6. Trials of other CNS active drugs
B
Ph3 rtnacol og i ca 1
and biochemical
studies
2 .
3-
4 .
5.
6.
7.
in vitro studies of candidate hal lucinogens on enzyme systems
a. Cholinesterases, b. Mono- and diamine oxidases, c. Glucose metabolism
of S. cerevisiae, d. d-amino acid oxidase
Effect of candidate compounds on rabbit body temperature
Effect on activity of mice
Gaddum rat uterus - inhibition of J-HTr^
Pharmacodynami c studies in the anesthetized dog , . .
Chronic toxicity and safety studies on promising compounds before trial
in man
Pharmacodynamic studies on optically active esters of choline
C. Chemical synthetic program
1. Synthesis of substituted piperidine carboxamides
2. Synthesis of aryl alkyl amine derivatives
3. Synthesis of indolyl alkyl amine
4. Synthesis of optically active esters of choline
5. Synthesis of a few additional salts of 2-dimethylammoethanoI
D. Clinical studies in schizophrenia
»
1. Continued trials of 2-dimethylaminoethanol in patients ....
2. Trial of naturally occurring sulph hydry l compounds in schizophrenia
WARDING NtyUQE
SENSITIVE INTEt/lGEr KE
SOURCES AND METHODS INVOLVED
*
/ The experimental subjects are a group of sixteen volunte- ers, l
U. S. Federal Penitentiary at Atlanta, Georgia. HcaUhy .and csnotional ly _ t
determined by psychometric tests) individuals are chosen. Their mean JS C £[ esen V
if ^years, their mean weight is 160 pounds. Their I.Qs. range iron $0 to *23-
Th"e~ doses of drugs are administered at random at weekly interva s. J 1 *
have exoariencedThe effects of central nervous system stimulants and depressants,
^y ait: to fy and to communicate the subjective responses to these drugs
and have proven that their responses are sonewhat reproducible.
Tests are carried out «qa hospital room. The subjects are encouraged to stay
in hVd durina the trials. Chugs are administered orally, two hours a ^ er 9
* a n na^breakfast jilt ng fa usual iy done single or double blind. The dru 9 sare_
S d 9 to eacJ Jbjelt H mall labeled bottlf. The label bears only the name of
the subject^ The subjects place the tablets or capsules in their mouth under
supervision of the physician and wash them down with a cup of J ,avore W
?he evaluation of the drug effects is based on throe types of responses.
A Observations are made by the attending doctor during a three-hour tes t pe^ _
following administration of the drug. These include P
sure, pulse rate, body temperature and hand stead, ness at 60 or 90 *tus
intervals. It also includes observations on the neurological and mental status _
of the subjects, such as alertness, sleep and arousal from sleep.
b A oersonal interview is made at the end of the three-hour period. In this jnter-
Clew Se suijecl !! encouraged to tellJiiS feelings under the Influence of the
drug and canpares them with similar or dissimilar effects which he may have ex
perienced with the other drugs on previous trials.
C. Twenty-four hour statement. The subjects prepare a written statement^ the ef-
fects^xperienced in the twenty-four hour period after the admini strat ion of t e
! X iuHrli for the effects were .iUbl.lsK.fb, the subjects thrives.
Subjects were told either after the Interview orafter they had ■ '
written statement which drug and dose had been administered. This '" cr ® 3 * 3 !
their degree of drug sophistication and allots them to evaluate new drug effects.
0 O W?* ?
A careful study of SAR of acetylcholine Ach and atropine-like compounds Indi-
cates that the naturally occurring Ach- like compound should have an asymmetric carbon
atom in the acid moiety. The evidence for the existence of Ach inbody fluids Is
tenuous since identification has been made only by Reineche precipitation which
method only tests for quaternary nitrogen containing compounds. A few of the optically
active acids which might be esterified with choline are lactic, pantothenic and as-
corbic .acid;. These analogues of Ach are therefore in process of being synthesized
to determine their pharmacodynamic effect.
H* -1,4
COMPOUNDS HAVING A POTENTIAL EPrECT UPON THE CENTRAL lrfiRVOUS SYSTEM
WITH SMFHASIS UPON MOIETIES ORIGINATING KALLUCIMTORY REACTS
by
«
d-
O UTLINE
of
Fourth Report
(January 1, - Nay JO, 1957)
I. 7hs v.'ork was continued in accordance with the outline of the Third Report,
submitted in December 19j^«
A. Substituted Piperidinecarboxamdes :
(1) compounds synthesised and postulated structure confirmed!.
a. 1 -raethyl -J-(N-!aethylcerboximido)-l^ 2,J,6- tetrahydropyridine
hydrochloride (C-j6)
b. 1-rae Ihy 1 - J- ( N- e thyl car boxer,! d o ) - 1 , 2,5,6-teirahydropyridine
hydrochloride (G-J7) , , . , n
c. l,l-bis/J-(N,N-di ethyl carboxeni do Jpiperidino/aethane IG-10T;
(2) work in progress: . .
a. synthesis of l-raethyl^-phenyl-4-(K,^dieUrylcarbox&mido;?iperi-
dine hydrochloride (G~JS)
B. Arylalkylaraine Derivatives!
(l) compounds synthesized and postulated structure confirmed.!
a, N,!;-diethyl-,t”bromopropionamide (GI-10J, X), intermediate .
b. N- phene thyl -N-'metJryl-,i-alamne diethylamide hydrochloride (Gl-104, XI J
. Indolvlalkylardne Derivatives:
(1) cos pounds synthesized and postulated structure confirmed :
a. ^-(N,ll“diethylanino)butyl 5,^,5-triijethoxybenzoate (GI*v , OJ J XXIX), ali-
phatic analogue of reserpine
b. 4-(K, N-dicthyl amino )bulyroruiril e (GI-551, mill), intermediate
c. 4-(lI,K-di ethyl emino)butyl amine (GI-JJ2, XXXI V), intermediate
(2) work in prdgress! ** ,
a. synthesis of ll-fh-Oh N-d i ethyl ami r.o) butyl/-}, * , J- tr ime .hoxyber.z-
eride (GI-JpJ, XXX), aliohatic analogue of reserpine
b. synthesis of l.'-formyl tr ypta.minc (C-I-201, XIV), intermediate
n addition to the work already in progress, new projects have been underta-
en.
A
Utilizing the products of
the effect of gradual cha:
our synthetic program, we are planning to study
igcs in molecular crr.stitution upon enzymes as-
iprr
*** >^-LV v *
' ■ o
Page Two
sociated with brain metabolism and, possibly, upon other pertinent bio-
chemical systems^ in vitro . Based on the information available at the pre-
sent tine, the systems listed below are being considered for the first se-
ries: of evaluative experiments. While we realize that their causal* connec-
tion wi"h halucinatory disturbances has not been conclusively established,
we feel that they constitute a suitable starting point. In each instance,
known psychotomimetic agents will be evaluated elong with our compounds,
(^'cholinesterases:
a. acetylch o linesterase (substrate! acetyl-*— methyl choline; compounds
studied: pyridine- and piperidinecarboxylic acid, erylallcylanine and
indolylalkyl amine derivatives^ effects studied: inhibition and/or
potentiation; method: VJarburg manometrie technique)
b. ps e ud ocholin es teres e (sub strate: butyryl choline and/or bensoylcho-
line; compounds studied: pyridine- and piperidinecarboxylic acid,
arylalkylr-mine and indolylalkylaiaine 'derivatives; effects studied:
inhibition and/or potentiation; method; War burg nanometric technique)
LSD was found to be a powerful inhibitor of pseudccholinesterase in hirzan
■serum and brain. Pseudocholinestere.se activity of rat, guinea-pig, rabbit,
. chicken and nonkey brain is much less sensitive to inhibition bjT LSD than
is the corresponding enzyme in human brain. ^Pseudocholinesterase was in-
hibited more powerfullylbylLSD than by other ergot alkaloids. (R. H. S.
Thompson, A. Tickiier and G. R^Webster, Brit, J. Pharmacol., 10: 6l, l?p5. )-
LSD was found to inhibith(5>05») ps eudo cho lincste rc se activity at a 1x10”® M«
concentration and was found to augnent_(5C5*)-the activity of the enzyme at
6x10 M. concentration. Siniler observations were reported for serotonin
( 5“hyd r oxy tryptani ne ) . (G. H, Fried and W. Antopol, Fed. Proc., 16:
Meperidine (l-methyl-^-phenyl-ti-carbethoxypiperidine) and other mrcotic
analgesics capable of producing hallucinations were reported to potentiate
(42-15SJ») the hydrolysis of benzoyl choline by pseudocholinesterase at con-
centrations ranging from 1CT' to lCT* 4 M, (S. G. Erdos and S, P. Shan or.
Fed, Proc., 16: ?31t l?p7*)- Tryptomine' and benzyl r-~: no (phenylnethylanine)
were found to activate (4*»-9p£j) the hydrolytic action of pseudocholinesterace
upon benzoylcholino, (E, G, Erdos, F. F. Foldcs, l. T » Eaart end S. P, Shanor,
Fed. Proc., 16: 2J»4, 1557^
amine oxidases:
a ? pon ox-ino oxi dase end b. d iamine oxid ase (substrate: arylalkylmine and
indolylalkylanine derivatives; compounds studied: known end potential
inhibitors, our pyridine- and piperidinecarboxylic acid derivatives;
..effects studied: inhibition and/or potentiation, evaluation of relation-
ships in the substrate affinities of the two enzymes; method: Y’erburg
nanoaetric technique)
Monoamine oxidase is considered to be a major catalyst of serotonin metabo-
lism in tissues. Iproniazid is reported to inhibit monoamine oxidase in tho
brain, but unable to penetrate to the site of r.onoenine oxidase in intact
cells of other tissues. (H. Vcisrbach, D. F. BogdaneM, B, Redfield end
S. Udenfriend, Fed. Proc., 16: ^*5, )- Relationships be tween monoamine
oxidase end diamine oxidase were reported. There is indication that the af-
finities of the two enzymes are overlaping; however, sor.e of their characte-
ristics have been found to retain their specificities. Mescaline (5,4,5-tri-
nethoxyphenethylRnine) ar.d tyranine were reported to be among the substrates
of diamine oxidase, while some JS-arsinoethyl imidazoles were found to be sub-
strates for Eonoe-rine oxidase. (E, A, Zeller, J. Earsky, L, A, Eleoiksma, and
J. C. Lzzanas, Fed, Proc., 16: ZJ6 , 1957«)-
Ssccharonyces cerevisiae:
3. cercvi siae (substrate: glucose; compounds studied: pyridine- end pipe-
( 2 )
(5)
c
c
^7 "(*
<
Pave Three
;srs nr« ^
•««** K " to f '^•^•.^.niuSlir.f S.^.riviiu. 1. U«
of our coupon* i <3 s upon, uie giyc-o 0 e
contemplated) ‘rinethoxyphenethylaaine) were reported to inhi- .
LSD M>d nescalme "” n f ^lucose) at 1 (T^ to lcH*
bit respiration 3}f S. cerevisiae (su^-a.e. 0 lu ■ J Co nfinia "eurolc- •
and 1CT 2 H, concentrations, respecti\e y^ ( . s»<-~ested that LSD induced
£ ica, U: 65 , -ves.^ Lrons ^ ^ te neU -
hallucinations i. Ur, Servemrzt, 2J. 3*
Sc! - »■ •* 1955 ; K
’• h^ss-m*«£ 1E-
paration of the following compounds: .
(1) the dl, 1 end-d isoners or lao^l choline
(2) the 1 end d isoiers of paniothenyl choline
(5) the choline ethers of 4- and ^ RSC ^4Lv4 e - P , re a, the postulated struc-
The dl-lactyl choline i odi d e^e P w s developed which my he of
K « *"» ' flt * 1M0W * f “*'
ses chemotherapeutic potentialities,
«• —
(2) ^p^at^ ' dtJl ** . fol!owi, «
acids: '
e. d-pantothenic acid
b, d-pantoic acid _ _
c, p— acetylarainobenzoic acid
a. dl-aaiidcjic »«** . . acid salts lmy, lei" prepared.
rhory University, l*ay 17, 1957*
Addi-
\
WA^Hli^G NOTIC E
SENSITIVE INuSAIGENCE
SOURCES AND METHODSJNVOLVED
o
o
PROPOSED BUDGET 1957-1958
j 1 ’C/iLi r ^,» -V-. £
V 7 -<1
gp^^avsws Grant to
Department of Pharmacology* Emory University
Carl C. Pfeiffer* Ph.D.* H.D.* Principal Investigator
June 1, 1957 - Hay }), 1958
PERSONNEL : Director* Ce'rl C. ■ Pfei ffe_r*(Part)
Asst. Prof.*>
Asst. Prof.* '
Research Asst.
Technician*
Technician*
Graduate Student
Secretary (Part)
Animal Attendant*'
1
24%0ASB
*5% Retirement
TOTAL PERSONNEL
Stipends for Human Volunteers
(Atlanta Federal Penitentiary)
Consumable supplies
Equipment
Travel
10% University Overhead
$ 3*000
$7*500
7*000
3*000
3*300
1*800
2*400
2*400
500
1*200
$ 32*100
444
. 1,075
$33*619
2*900
2*000
4,000
1*500
$ 7*500
$33*619
$ 2*900
$ 7*500
$44*019
4*402
TOTAL BUDGET
$48*421
SENS
SOURCES
,VEO
p. pi c (s .
V ' r
H*
} PROPOSED BUDGET 1956-1957
■■■.. ...g. — f. ,, i*r;> -inf »<■> Ffrimy University. Dept» ©f Pharmacology
^C^cTPmffer, Fh. P., H.D., Principal Investigator
June 1, 1956 - fey 31» 1957
P ERSONNE L I
Asst. Prof.,-
. Asst. Prof.V'^SSBW.'ii^
Consultant, Carl C. : Pfeiffer*!
Research Asst .
Technici
Technician l «^^^^*(l/2)
Technlcien/^lj^
Graduate Student
Secretary (Part)
Annimal Attendant,
7,200
6,500
3,000
3,000
3,000
1,800
3,000
2,<00
500
1,100
^ 2 % OASB * ’ ■ ' .
. 524 .
*5j£ Retireosnt ’
• _ J & 3 &
total personnel
$ 31,500
$ 31,500
Stipends for Huaan Volunteers
(Atlanta Federal Penitentiary)
$ 2,000
$ 2,000
Consumable Supplies
Equipment
Travel
$ 2,094
6,000
1 jl 500 •
$ 9,594
12x594
It# University Overhead
$ 4,309
$ 43,094
$ 47,403
TOTAL BUDGET
-V
•?- A r «
-?
0 bank
: *7'' y .-- ;• y. -f y& : y
.* TT This is a final Invoice, A total of $56,174,34 V/as obligated c '. , •
.i > this subproject during FY 55. Ilowevcr since It Is 'anticipated -y\ ". T-
IfiP^.-r.that additional funds ^ill be obligated for this project*. the flics
Wp^T -: */ f : ;^ h<>uW ' °° l be Closed. „ ' / ^ j. ^r \ ^ ‘ 7 :'<"7?7sy'
RECEivtb.2^. ; y v ;>>• • v>
A ‘ m ' f. V* j \~-V ^ "• . .. * •/ * . • i
‘ \i ; .*.'V'.’SlbN E Y COT TLr
UEB
'*.ms*&sw • •% 364 -s^" .. i .••**' •••;• *a * •■, ?* ‘ *** ‘.Chief - . .. .
. . ; . •*.* I* ; -..v •. v- v ’ -V?* .'-TS-S/Cheu'Ical Division .•
i- V* ‘r* Attachments J •’ "•*• :* V ’’ • .'•• ••:•'••
. .*"’v j -/. 1 I . , • * i - - . _
• > V. v -i(s'.
Invoice &
Distribution: ^ r/.T *
y ^:^'° rl34 ? '^ drcs “? _..'
Certification, “ ■• . ■. 'I fitter rvj !«w
** ‘ 'V l * 1 * • • ovj'ci /& *
1 *“ Comptroller •■•- •’. •.-. v
•• ” ■' ^i-^ssLBAso. - *ef£jL- ~
. . . y2 - TSS/CO ; . • .• • ' • ‘ l ], / •
/ ' !•• TSS/CD:.|^^gA^ s SeHe;nbw c >' '
•• • • " • ^ t-,* • .*. / 74 . . ■
> Jk ^. •' , ': TSS/CD: (ll : beptq;jibef lyn/^T / .
TKE . AM ^ v * ■ - -.' ~JB 0
M r , .*•*-, *.. *• - S ‘ • • •• . .
For services
INVOICE
r
\
CERTIFICATIONS
(I) U Is hereby?: entitled .hat thU Is jnvol ^ * *»*»
V°l\L are be.n* accomplished.,.
Z'^i/cn. *- .ha, payment .here-
has not vet been made.
Chief, TSS/C hem leal Division
Date:
m It Is hereby certified tbat thls Invoice applies to Subproject 47
from the DCI to the DD/A, and the extension of this authority..,
subsequent memoranda.
Re s e arch Dlrec tor
-Date;
shotifd Arcade payable
a^lnvoices w»U folio* later. •;? . £$%.
:t ; .-. ' -, ‘..'J - ' • V ' pi.*'.* forward tbe checks lo Cblaf, TSS/ChcnJlcal Dlvl- .. r'i ’ *
1
: f V-*-' : - 0rl * & 2 • Addressee . . ; .. ; *- • v — * . ;•■• >
••;v.* r --- I • Cor&plr oiler • :
: '}' '•■ . • I* ? ?•' *. ■
.'•■T; '• "■*■ V* % ?* ;**>£*,• ?-*^. SS / CD ^ V v ' ' V.v. .nHECgpSgS^I THE AMnUNT 'OF.'$£*^'
For services
r
.'4te'i
V? "
invoice
: v CERTIFICATIONS
> ** * ‘
(1) It Is hereby certified that this Is Invoice No. 4 applying to Sub-
proiect 47 of MKULTRA, that performance Is satisfactory, that the
services are being accomplished in accordance with mutual agree-
ments, that a detailed agenda of the payments and receipts is on file
in TSS/CD, that this bill Is just and correct and that payment thereof
has not yet been made. :
I
I
«
i
i
*
Acting Chie?~ TSS/Chemical Division
Date:
(2) It Is hereby certified that this Invoice applies to Subproject 41
of MKULTRA which was duly approved, and that the project Is being
carried out in accordance with the memorandum dated 13 April 1953
from the DCI to the DD/A, and the extension of this authority In
subsequent memoranda.
Research Director ■
Date:
staisii
Uj ^ ^
1 June 1958
:• MEMORANDUM FOR: COMPTROLLER
ATTENTION * Finance DIvIsloa
SUBJECT
s
■\ \
MKULTRA Subproject IT,
Additional Authorisation II
1 u ft der life authority granted In the nsemoranduaa -
dated 13 A^rll 1853 from the DCItoth. OOjAwi the «te"el°»
of this authority to subsequent rnemoraode, . .byrojecl « » *
crevlously approved. Under the same authorlty an additional^
euin ot MV, 299.12 b.j hern euthorl.ed to « v . c *
.rj.eii.ci (thereby brtotlhe the funds eblU*'«.<( ■lurlol i V 55
a total of $38,174,31). -• ; I
2. This expenditure should be charged against Allot-*
inenl G- 2502 - 10 - 001 ,
I CERTIFY T J A1 FUNDS A*.E AVAIIA^IE,^ ^
CH'OMiCm l t M'.uCf N». e ?yi?j — .
CKMOl TO AlUflMlMI £~ ' £>e> "
AUTHORING OFFICER
Distribution: p ,- f
Orlg & 2 - Addressee
V .1— TSS/OC
tss/^a^^'8
1 - TSS/SRB
2 - TSS/CD
n*" i/.viimI f--,
TSS/CD/4*tP{» Jun 38)-
MONEY GOT f UK B,~ Chief,
TSS/Chertlcal Division
APPROVED FOR
OBLIGATION OF FUNDS:
camion
(O'
T>oih^TS£
fcy cuyforii^
date
12 1
* v ’ • *• • «
r
167475
A
DR A FTJ
7 June 1956
MEMORANDUM FOR: THE RECORD
SUBJECT : MKULTRA, Subproject 4?
hl^The purpose of this project is to provide funds to
continue the research program conducted by Dr. Carl Pfeiffer
at £n--x>rySJ«4-versity. This program is designed to exploit all
'he knowledge and facilities available to its director in pro*
viding answers to specific questions of direct interest to the
agency. In addition, those areas of basic knowledge required
to provide these practicalanswers 'will' be developed^ It
should be noted that although the attached proposal ofescribes
the facilities which will be used in the study/ the program
itself was deliberately described in general overt terms in
order to comply with its unclassified stales.
2, In view of the above it is desired to describe more
specifically the various phases of the general program here.
I
I
(a)
A relatively small part of. the program
will be in the fundamental held of the
relationship of structure to activity.
This basic study will be of an overt
nature and will serve the purpose of
maintaining cover for the£
‘.support of the program.
*
TCT VUwl:Ut"
mmmm
- ??
yj.
JUJU
o
Sk*»
r
'/?■ - 7 - 7 -
A second phase will be represented by
an extensive effort on behalf of Dr.
Pfeiffer to find a solution to the re-
quirement for an anti-interrogation
drug. This requirement was laid on
TSS^Chemical Division by another
Agepcy component, •
(e) A third phase of the program wilt
provide screening and evaluation
of compounds submitted by TSS/CD.
including the phases involving tests
\jn human volunteers,
3. The
cutout in the usual manners -3
4. Costs for this program for a period of one year
beginning 1 June 1956 are estimated to be $47, 403. 00, to
O => . ^
which must be added a four percent (4f e ) fee to the'
4g^S&t -. making the total amount $49,299.12.
5. Th e | P^^^lj^ ^^&thas requested Emory
University to submit to them a summary accounting on an
annual basis of atlTnbnies received from the Fund. Also,
it has been requested that any unexpended funds be returned
as soon as possible upon the close of the grant year.
5
■' 6. The requirement for a six months informal
i " accounting on the part of the principal investigator is waived.
^ ?. Title lo any permanent equipment purchased by
funds granted the University shall be retained by the
University in lieu of higher overhead rates.
' 8. In connection with travel under this project, it is
agreed that the Agency will accept the travel documentation.
- vy :•••' and accounting which conform with the practices of the
! University.
9. It is agreed that technical reports reflecting the
progress of the research program shall be submitted at
; mutually acceptable intervals.
j
!
I
!
i
f
t
I
i
TSS/Chemical Division
APPROVED:
4
Attachment:
Proposal & Budget
Sidney GottHeof Chief,
TSS/Chemical Division
APPROVED FOR
OBLIGATION OF FUNDS:
I
Research Director
a
t
Distribution:
Original Only - -T-S5 /CD
'“V -;itv jff: 137475
V/ auy^° rlv */ , >
eats / Jv.ne/9? 7 _ yi
PROPOSAL
It is proposed to continue the work at Emory University
which has been conducted during the last two years by Dr. Carl
•*
C. Pfeiffer under the; nominal title, "The Phr rmacological Screening
and Evaluation of Chemical Compounds Having Central Nervous
System Activities."
The program at Emory is necessarily divided into several
parts, some of Which are supported by grants other than that of
the Which are operated as integral parts of
the program. Other agencies who contribute are Emory University
and the U. 1 S. Piiblic Health' SeVvice.
Facilities which contribute a major portion of their capacity
toward the program are as follows:
1. rart i om Laboratories at
Emory University under the direction of
k 2 . Neuropharroacology and Electropnysiology Xabora-
^torics.a t Ero or y Un i v er s ity und er the d i r e c t i on
Cc.-V-ied ly/immiMl
iy jf j / 3 7475
cat/: I3?7 /
n
V, ' •-•*«»#
( 2 )
42--? ?•
*
iA-
General Animal Pharmacology Laboratories at
Emory University under the direction of
Professor. Carl C. Pfeiffer.
Behavioral Psychology CaVoratories (Animal)
under the direction of the Department of
Psychology at Ernorv Uhive^rsit^with auxilliary
animal testing laboratories under the direction
L in the Department of
Pharmacology. . • • .
Facilities for pr e 1 i min ary h u m a n phar macological
testing
6. Facilities for testing in normal h um an volunteers
at Atlanta Federal Penitentiar y directe d by
Professor Pfeiffer.
The general program to be continued by these various
facilities is the discovery and com plete screening and testing-
of a number of materials capable of producing alterations in
the human central nervous system which are reflected as alterations
in human behavior. ... Such fundamental research on mechanisms
of action and structure-activity relationships as is necessary to the
consistent productiomof such materials will be undertaken as re-
quired in addition to the practical evaluatiorTofltiem. Compounds
from many sources will be evaluated in addition to those of special
interest to the
Several particularprojects for the coining ye ar hav e been
discussed with the representative and plans are
• — r- —
being made to carry these out in addition to any others which may
arise during the ye ar, fhese particular pr ojects are as follows:
1. To evaluate the effects of large dcses of
LSD -25 in normal human volunteers.
2, To evaluate the threshold dose levels in
hurnans of a particular natural product to
be supplied by t This
*- -
evaluation presents difficulties of a nature
which makes it a unique problem.
3. To evaluate in human beings a substance
which we now believe has the ability to
counteract the inebriating effects-of ethyl
alcohol.
•V#.
187475
o
HI-- ¥h
- - ; “ rr BY 187475 V? PROPOSED BUPGcT 1956-1957
•E2 H-^liSa^&B^&Grant-to- Emory University, Dept, of Pharmacology
Carl C. Pfeiffer, Fh.D., M.D., Principal Investigator
^ 195?
PERSONNEL ;
Asst. Prof.,
Asst. Prof.,'
Consultant, -Carl
Research Asst.
Technician,
Technician,
Technician,^!
Graduate Student
Secretary (Part)
Annixnal Attendant, 1
$ 7,200
6,500
3,000 — -
3,000 .
3,000
1,800
3,000
2,400
500
1,100
2% OASB
*b% Retirement
524
835
total personnel — $31,500,
i'sti
Stipends for Human
(Atlanta Federal
Volunteers
Penitenti ary)
$ 2,000
$31,500
$ 2,000
Consumable Supplies
Equipment
Travel
\G% University Overhead
$2,094
6,000
1.500
$ 9,594 5-9^594
$43,094
$4,309 _4j309
TOTAL BUDGET
$47,403
A
i -
i
c
c-
7 -?*
eh»y university
!rant
Department of Ph armacology
Dr. Carl C» Pfeiffer^ Director
Siaror/ Of Receipt 8 and Expenditures forthe Period
June 1, 1955 through May 31, 195°
Vpaxpeodsd. balance IHy 31* 1951^
Received fro* this period
■Total funds available Ttbls period
Direct ^^>curfiturca if
Personnel
Hunan subjects
Travel
Equipment
Expendable Supp lies
Total Direct Expenditures
Contribution to Indirect Cost
Total Expenditures
Unexpended Balance ft 8 of hfey 31, 195$
21,538.94
1C6.C0
1,651.45
18,659.43
3,982.10
lilt
♦ 161.85
litMao
♦51,954*95
♦ .^377^38
« See attached schedules
Approved!
Every University
e-A_>
Carl C. Pfeiffer, M.D.
Project Director
— “* ' l EvcH E. Be 8 sent , C.P.A.
X .Controller --
I have exa-ined and approved the submitted
expenditures. - *
y - J
sl< A
s inn
CbJ/'
. tSS/Cbemical Division
Date: AUG l 5 *056
r
C:
rcby mixmsin
’ Department of K*rtaacology
Dr. Carl C» Pfeiffer, Director
W ?
7-^
g3£i$m
'£V'- ^ r , '^S^l
Position
LeV, >M4 1
Asst. Professor
Professor
Student Research Asst,
Student Research Asst*
Technician,,
Research Assistant ■.
Student Asst,
Instructor
r
t Student Aest.
S tndeht A&at*
Student ■
Student ’
Student
Instructor
T.I.A.A. - Dr. C. C. Pfeiffer
Social Sec urit y
Total Personnel r: TT
4
Amount
VT9*
6.799.
3,000.
800 .
1.800.
2,690.
• 800.
*99.
2,916.
. **99<
I90,
100 ,
15'
31 '
11,
200 .
150.
£4$. 71
llumn Subjects
$ 106.00
frpendi tuxes? 03 a " 3 .- a ?P r °red the euh'mitted
Pate;
8 8& 8 8 S'&'Q S&8 8888^
»DRY IffilVESSm
tsecartaent of Fbarcn oology
Dr,'C8.rl C. Wei^fer, Director
*
i*
: ' 17 M73*
- ?/
tv C C . 'Pfe if/er KlXle^ v me , Georgia
Dr, C. C. Pfeiffer
« lava City, leva, Minneapolis
m®
v --
Dr. C. C. Pfeiffer
Dr. c. C. Pfeiffer
Dr. C. C. Pfeiffer
Dr. C, C % f;feiffer
■ Mina . ;
■*? >W 5 f 4 S»
y v v>i *ac\
Amount
n.uo
105.61
251 * 12 ^
61.80
96.96
51.55
% 251,29
100.91
103.16
Dr. C. cr Pfeiffer
Chicago, H.Y.C., Vash»,D.C».
93.66
99.16
73 .?a
161.86
Total Travel
$ 1 , 651^5
*
J fc'at. Warning
•• *»"«* tt» w*,| Hm
D»t«:
Bepartiiicat of lharro&cology
De. Carl e# Pfeiffer, Director
"asagsass*
v? --?r
EDCPjariWBLB SUPPLIES
Item
'..Amount
Kcedlo valve
Chemicals, stoppers and
stopcock
Dogs , •
Tape, Jhrs, celeuose vipes
Alcohol
Staples, writing pen
Collection c&rrette tubes .
Trans forcer s
C heed oils
Cher deal 8
Drugs
Mice
Che.nl cal 8
Long distance telephone ‘
Mice
Laundry
Stationery, tai>e, jalneo
paper
Mice
Laundry
Freight
Chemical*
Paper, rubber bands, labels
Drugs
Alcohol
Chemical*
Magnifier, filter poper
Stirring rod
Chemicals
Babbits
Drug testing
porcelain balls, chemicals
Resistors
Cocaine
Gun
Mice
Tubes, electronic
Cabinet/ S:«*ng$ a .~i ncd and
Laundry expend! tuxes.
f 3.98
22,75
20,00
17.18
3.20
2.75
17.70
52.51
16.28
23.C4
13.63
171.26
21.89
6.11
187.46
28.13
. 18.00
214.24
3V, 89
10.52
21.95
9.60
52.90
2.33
40.64
13.96-
5.30
9.79
15*45
5.00
26.84
27.67
95*55
18
5.41
appref,l3>i
SlDNSy/ToiTLIiS
Chief
I tea _
Bottles, stirring ro«5s,
chemicals
Aniiril Food
Animal food
Drugs
Bottles : ; :
Cbcnical deterrinatlons
Chemicals, glass vare
Mica
Mica
Acid'
Tank regulator
Drug testing
Actylena
Scissors & Stethospopo
Pulleys 1 1
Electrics! supplies
C-lassvara
' Chemicals, glassvars —
' Plastic containers
Oxygen & cyclopropane
‘ regulator ;
‘Silver plating solution
‘ Guinea pigs
Chemical determinations
Postage
Photographic work
if RabbitH
' Repair typewriter
Batteries, thcrDonctcrs,
drugs
Chemicals
Syringe .
Lab. tools
Bicycle tire
Chemicals
' Chemical determinations
’ Antral food
' Laundry
ie ■
Sub-total
Amount .
56 ,4i
49.44
13.02
12.90
5.56
CoM
333.30
149.89
18,85
13.28
42.13
15.00
5.04
58.61
51.55
76.72
2f.44
78.02
4H.99
76.63
15.45
10.30
21.01
50.00
73.50
39.14
16.75
23,05
234.02
5.50
3.45
2,4l
27.86
26.78
67.77
■ J$
43,200.92
2518 : AUdi s
JSS/Cheaical Division
1 QG£
V * \
HOFSan&BI.? SUPPJ.TES
Balance Forward .' $•
Chemicals, porcelain ball*
Cedar shavings '
Glassrvare, stoppers, chealcals
Motor, cabinet, lanp '»
Cocanut oil soap . 7
Ani cal food • Z ‘
Claes cutting discs .
Drugs, cellulose vipe* •
Rabbits ^
fringes ’ .
Fila processing
Chemical* .■
Mice ...
Animl food
Laundry
Brill rod, bran plate
Keedles
Cboalcal*
Cteaicals
Amplifiers, bulb scooter*
Cbeaical detemicatlocs .
FiVa processing
Chemicals ‘ . .•
Claesvare, chemicals, tubing
Guinea pig*
Freight
Drugs ...
Motor count pulley 7 • -
Chenlcals
Tuba tester, lubes,' Vrencbes
Vials, chemicals, cotton
Kisc. record supplies
pipe flanges & rod
Bog# ^
Sponges, drugs
Tape
Photographic vork
Dental daa
Tree leg paper
Fila
Book - Lab, reference
Laundry
Chenical detemirations
laundry
Freight
Antral food
Chemical •
Tensolite
Anlnal fool
Amount ,
*,206.92
• 88,39
10.30 5
104.34
35.31
12.75
67.Tr
ey.ai
17.10
10.30::
io.it:
• Long distance telepJiou*
Pike, flash-o-lenf
Glassvare
Fila processing
Ter.sollte virs ;
, Freight, postage
Photographic vork
Fila
Tubing, stoppers
~ Cord, brass rod .
F l>o too tat __T.
Drugs * ’ •
15,58 Mi sc. record supplies
Ul.68 . P lex iglas *
101 .00 Capsule* y
15.45
86.16
80.03
89.08
' **2.73
14.00
32.74
35.50
3.00
10.15
380.60
20760
1.99
13.28
73.61
14.63
5.88
23.74
30.64
8.03
85.00
24.40
6.46
59-50
4.02
10.61
: Anlial food • '
: Springes, needle*
Laundry :
G iassVAre . ch em icals , tubing
Insulators, vire
Bicycle tube
Oicmicals
Chemical* ■ ■
Da ta r eco rd in g supplies :
Aroirnt
15.35
17.65
183.25
6.00
18.41
41.73
icg. 50
4.50.
19.08
12.46
1.80
3.00
74.52
30,16
30.90
13.02
30.007
46.06
34.46
12.49
2.6oz
7.56
22.01
42.00
Total Expendable Supplies $5.4 39.6 5
Kavo
e -J the
13 .91 -AfjQ al ®^isloa
■ , 5 'SS S
80.60
16.71
4.39
83.18
17.54
3.28
48.41
o
o
EMORY UNIVERSITY
DEPARTMENT OF PHARMACOLOGY
f
STATEMENT OF EXPENDITURES FROM 1
•GRANT AS OF JANUARY 31, 1956
^7
--- . CATEGOR Y . ALLOTMENT _ EXPENDITURES
Personnel §30,227.00 $21,985.82 (Approx.)
Travel .\ 1,500.00 91U.8U
,'i
Equipment ' ' — 6,000.00 2,537-18
Supplement* 8,000.00 7,699*25
Supplies 2,098*00 — 2,573*69
Overhead 3,982.10 2,651.5 2 (Approx . )
TOTAL §51,803.10 38,362.30
BALANCE as of January 31, 1956 $13,880,80
1
4
-^Supplementary Equipment allowance for purchase of
BocVr; an DK-2 spectrophotometer. . '/A
1
r
Grant
Department of pharmacology
Dr. Carl C. Pfeiffer, Director
' EQUiPhKrr
Itea
Yiso-cardetto -■ Couplets
Flans attaohnent, Burner standard#
Johiison-Kries Stcrootuxie
Lathe Ml attacbrjeots “ ~ r_:
Stop vatch and holder
2 tele -thenaocse ter pi'obe
DX’Z Spectrophotooator •
Additional cost - exchange of preanpltfler*
Dyna-puicp ■
St llT©f
Utility cart, >apor la^p, balance circulating system
Baodeav, Bench, Blades
Tljue drive attachment for Spectrophoto^ter
Lab. Jack
Freight on equipment ===== ====ddd:
Of f oer Electros ncephalozraph -o channel ^ -. : ..
2 Kotyolnt refrigerators - 12 cu. ft.
Typewriter
Ecfractccseter, B & I» . .
Kodak - K100, leas, telephoto, projector
K-100 viewer, 15 ®a lens, pro jec to -editor splicer
Apex tape recorder =--=-
Convert 3 Tele -theraoae tors
Total EqulprjOnt
Aoount
$ 816,27
5^5.90
234.88
T57.&T
22.61
159.^5
7,699.25
10.20
37.06
66.95
476.89
96.74
298.70
36.9V
62.88
3,962.93
683.82
373.24
715.65
687.56
103.66
731.30
83.31
$ 18,869 .43
1 hav * examined and
expenditures.
approved the Bubal tied
hate;
SlDiSY GjSTTLlZB
Chief
fSS/Chealcal Dlvlsi
on
.. ~ .- m
'. %: ;» «-'*f.v% : j£.s
^’iV- >. *
/ter*.
• ? -•
*£. ?
_fr :*
: — . — _ • - -«• mS^^OKKTIAl*
V ?^' l ^«,u.w**cJ />^'OP WW noM,
■ ^ .* _ j
Central Intelligence Agency . *Y t ' . r
OFFICIAL ROUTING SLIP - ->
SECRET
31 Octo’bgr 19^5 -_ -
TO
' i .
2 -
s’.
4
5
[from
A
TSS/CD
initials
date
[Tli] APPROVAL ‘ IHEORMATION
err action - C7 1T direct replt
comment . uznmnmm of refit ■ L_
CONCURRENCE ( . 1 RECOMMENDATION
Remarks! '.!},•.<?. ^
SIGNATURE
[ ; ] return
DISPATCH
FILE
secret
confident lal
hiu O. on- 4 : ’ p «Tto“. »
1*00} OU *»
UNCLAS SIFIE D
— 1 * 0 )
;rfTJ*S o/rltl
MEMORANDUM OF AGREEMENT
V v
t/.T-
The purpose of this memorandum of agreement Is to set forth the
mutual administrative responsibilities of the principal research
investigator and the sponsor. Therefore, it is mutually agreed that,
A, The principal investigator shall submit to the sponsor, at
six month intervals, an informal statement of expenditures of monies
advanced for research activities. It is requested that the statement
be submitted in essentiall y the following formt
- • . %
Personal Compensation
(Salaries, Subject Fees)
Equipment
Supplies and Services .
Contingencies
Overhead
B, It is understood that any travel expenses incurred in the _
furtherance of the research program will be accounted to the University
in a manner consistent vith its established practices and policies.
I
C, The principal investigator shall submit to the sponsor
semi-annual reports on the technical progress of the research covered
by these funds, ^
D, Title to any permanent equipment shall be retained by the
University in lieu of higher overhead rates.
EMORY UNIVERSITY
Emory Universuy. Gyohgia
Department of Pharmacology
October 5, 1955
<60
I
■ «
3
fts one of the favored recipients of grants from thd
x vish to thank you for the support of
research program for the past
our basic chemical and P^/^olog^ rftlat ionshio with the
es are
^ baS5 ? s Ch Tt C ?s Z hope^that our close relationship with the
SSrXtT of theW^^^ V6 ' ° UrSelV '
continuing to expand our interests m Jus field.
T have obtained an accurate quotation on the
Kodel S°-2 Becton receding cpeclroFkotcneter and Ike can t.
listed as follows*.
*
1 T'odel DK-2 Beckman recording spectrophotometer
1 "Time-drive" attachment for above ^
y% Georgia sales tax TOTAL
$7,b?5.00
290.00
233.00
$7,998700
Yours sincerely.
Carl C. Pfeiffer, hA>.
CCPsba
WARNING NOHCE
SENSITIVE INTELLIGENCE
SOURCES AND METHODS INVOLVED
MEMORANDUM RECEIPT
git October 1955
CAU
11 0«^‘ST 1955
' • -V. v ' ♦, . * . "*• ‘ •
* '• « • V MiW’'?I!iAKCE 01Y1SIOS
IvmmKDUHFCRl cailff ***** ...
VIJL .: i>
SUMICt . • Su.tetnt W^-iof 51
' ' S rlna r^rojeci,
l - * »«* u t * u *s’ ;■ .. • • •
iv i# m *** 1 * 4 **"Tv -- ; - — - ''tfpmJ&a&G "
s» £ • b 1 . “v ^" 4
$>20.00* • ; _ /.: : .;v r; . mee/Qutdci
$>20,00* - - yy ^ ^ ^ lefj *ss/Ch**lcal
nc ^ r ,
195?. ‘ . ,. ■ . *v- toUl
3 TWL» invoice 6 lncs it i«
VUe r* 5 ^J» cV * f
SIMS* -OOTIL 1 I 8
(M*f ' ,
XSS^Ckt^G * 4 DIyI*^ 0 ®
: ::
1 - Coc^pVrpi>*F
1 - T SS/^A 53
-. — ^2 - TSS/CD
A
^/to^feKlO Oetcfcwr -WJ)
For ssrrl««*
INVOICE
''.V'-’." ■ ■ *3,320.00
CtfVTJflCATIOSS
( 1 ) It 1 . Ur.ty urtlflil tUt IMt It ^“’^f^S^tUt
Sobf>iroJ«ot 47 tf l v ^b j-st-.ul »grM-
.ooortjBC. ^““ rs . <lpU I, on
th«wf b»* BoV);*t b»« wdi.
ChiTf, TSs/^slc*! DIvIsioa
P*t»l
(2) It it b«r»by c*rtifi*i tliAt tblf if b*lng
*aib»*QU*nt is»nior*a4f « .
•*, Btsorcb Director
Ditfi
t
I
i
»
I
l
26 September 1955
FCRi
aitojiio* *
1
CCHPBSOLLIB
Jfjuawi* Divisloa
kniim S%roJe<* 47, A4diUor.a AuttwItaUoa.
No. 2
\
(Mar U.« .ateOTlty erwl^ In U,e
7AlYil7^ r ^^
Coder the easa cuthorHy ea addUlocal f.w e b T brltvliu
£*”£2 £ sr«a» d«ri4 n w k» .#**«
to AlloUoat ' ‘
SIDNEI G0TTLB3
Chief
TSS/Cboilcal Division
ah&kfd yea •
OBLIGATI® or rms
EofMni Dir color
Pate* l
Dlflrllwttral z
Orig 12 - A ddrasso#
1 - TSS/OC
_1 - tss/pass
1 - TSS/SRB
2 - TSS/CD ‘
/W*
► cs *•• avatw*
*v • -• ' J C^flvtiL
(26 ^opleaber 1955)
'V. ,y:"
vTrrr.,'.!
H Octobar 1955
<{
Ifflfiief FCBl .<3«S? # FIKAKCB DlVISiOS ‘ ■ ~ ; ; .
yjx' i - * tss>^t»d$«i ■ ;. -, < -
vnjraf » WTOLTCA Sabprojtcl ^ ^^volc# /^# .
smt{ * : .■ Allots 6^502-10-001 .
Tv0 ,„ U«r'. <*«*», |
S'? ,„«. „f m.o».oo* 5~H>* t*^ 4 ehl>ci f< * r
s s:
MTlrfoa, tbrou# ?SS/Bu**al Of f icer, »o 1*™. , .,
1955* ' ' ' .-; • . ■
3 . THl* lnvolc# roprasfnls ilocl ttU
ourr^Uy ba ; obU £ .Ve4 vn^ar
T*
- siDtiTf corftus
Chlrf
IS^Cbrilctl DlrJclon
itUcb’sanli* .„
Invole* 6 Cartlflcitioa#
| CiSTI'Y TSM fUNDS A"! A\A’*.«U:
il :«:sci C/P-
{, f.ai 1 C J.'.;C‘v! , l *•• /-.IJ'J i-
12 --.V. ■" -
DielrlbuHoal p.cr
Orlg & 2 - M4rt*w*_ f£-
; f l - •
2 - TSS/CO — C H E C Y$2j2&3 K 1: ’£
RECEIVEJ^O?^
TSS/CDj^.(lO OQlobar 1955)^ ^
Ct.cXr..- -a^Se jN.jH-S AMGUfvv UK £-£<#-
F^ECEiVEG*.
S -
»-V.- i*
kvlif.
a*'.
| Doungrn^nl
. by authority
rat
->’• *•*
87475
IWT'S?
r
c
draft/^
5 October 1955
4 ? - 4r</
MEMORANDUM FCR: THE RECORD
SUBJECT * KK ULTRA Subproject 47, Additional Authorization
i .
1 Dr Carl 'Pfeiffer. Professor of Pharmacology, E^ory
University Medical"' School, is currently engaged in thejjti cdy of
affecting 'the central nervous system. In addition. Dr.
Pfeiffer also conducts a screening *" d cv ’ d ^° Q pr ® gr ‘* °
materials of pharmacological interest to 1SS/CD.
^Uo'Lcordin* ^^ropho^t.r-^M
.*&»««•* «-
instrument, see the attached proposal.
id, 320.00. Charges should be made against Allotment
4. In accordance with the Memorandum of ^derslanding ‘
with Dr. Pfeiffer, the_University“shalVr'et*ap ;
pernanent equipment. This is f . . ts pfciffer-is
v,.„ o t tfce HporU™. •» W vlll E .t.rl.U,
of the manner in which these grants in ■ r . rovl L the
considerations make it undesirable to attempt to f*°^ d ^
equipment on a loan basis or otherwise retain title to it.
c rh»0^mSBS0S^t » 3 ^ade arrangements for the
the Fund.
it
Dqhrngrn
by either
cate: Ju
E8 IlfPtt
- 2 -
6. The present program with Dr, Pfeiffer extends to 30 June
1956, It is anticipated that TSS/® will desire to continue
utilizing the services of Dr, Pfeiffer for an indefinite period
beyond that date, by giving further grants for research activities.
Prior to actually turning the funds f or the spectrophotometer over
to Dr. Pfeiffer, TSS/GD (through the will obtain Q
a' statement from him to the effe ct th at he is favorable to a con-
tinuing relationship with "
" *
7. Dr. Pfeiffer holds a TOP SECRET approval for work under
Project KKULffiA.
'r.ief, TSS/ Chemical Division
APPROVED :
fr
Research Director
Date : Otk. 6-
Distributions
Original Only - TSS/CD
ty aul^ny'^F l8747 \ O
eate:/J une
C Ii BY 167475
Pharmacology Department
EMORY UNIVERSITY
Emory University. Georgia
August 18, 19$$
-.•*»: •• U&5^' « S—V , . 'A.£w4
ggf&t*
I was advised by your representative,
one of oxir special research needs might be considered by the^^A^PfeR
Specifically we need for research purposes
in me^al^se^e aEecVrian DK~2 ratio recording Spectrophotometer.
This would be used for the following purposes;
1) Routine assay ^for purity in those compounds synthesized by
or those compounds which he isolates from
natural sources. .
2) Use for monitoring rapid chemical __ reactions in biological
systems,
a) The combination of convulsant acridone with deoxyribo-
nucleic acid or ribonucleic acid.
b) The combination of pyridoxal phosphate with thiocarbo-
hydrazide,
c) The modification of epinephrine by schisophrenic serum
and cerebrospinal fluid. Heath reports a marled difference
in light absorption with time that is characteristic of
schisophrenic serum.
The cost of this basic unit is $7,ll7£.00, but with the vaver
length hold attachment and sales tax the total cost would be about
$8,000.00.
Yours sincerely,
Carl C. Pfeiffer, ¥.&./>S
CCP:eJ Professor and Chairman
t«ncr«. 4 A„. CKfrf),.,
“T v of: Mh 1
talc: Jurji 1977 / /
£o T’“7 s ’ 1 ~-r '
BY 18/4?5
For services
IN70ICS
#30,971.22
cmiricmoNS
(1) It is hereby certified that this Is Invoice §Z aPP 1 ?} 1 *
to Subproject 47 of MTOMWL; that performance is-wUsf*9.£*r»
^t thTearvices are bolng accomplished in accordance VitJ ^tug.
a*r Joints, that a detailed agon, la of the parents and rec
off Us in TSS/O, that this bUl Is Just and correct and that pay-
Kftat thereof has not yet b ean Rads.
Date I
Chief, fSS/Sealcal Division
(2) It Is hereby certified that this invoice applies Jo Sjh-
nroieot 47 under MEUWJU vhloh was duly approved and that the
folsct is being carried out In accordance vith the »e:aorsndum
Siri 3 AprIl l93 ^^ the DCI to the DD/A, and the pension
of this authority in eubse^uent jeasoranda.
Feefrsreh Director
Date l
r
becfipt
■?
I b3T«V .cV°vl*4* ««»** d ’ ,0i *'
„ . y the amount of ■*'-'»
! rMB “ S!S fesf to to. .=»** Of tM.OW.Mi'
fsp: s:s i#£ «« ^ * * 9 "- 54 * *■
***^* 10
#29,80?. 10,^47
#1,163.12, 1
in the amount of #2?,Q??.?4>
o^g^la the amount of #93-7.3## /
r
r-
19 September 1955
H ?- if
mmmm tor « chuff,. fbiancb pimios
fix i TSS/&udget Officer . ■ ■ •
*" V
SUBJKTf I KSUU3U Suhjtfo J eat 47, ImAce #2 -
^UoUent 5 - 2502 - 10-501 & 6 - 2502 - 10-001
1. Invoice fZ i 8 attached covering the abore subproject.
This is a final Invoice. It Is requested that payaeat he Bade
as follows* &
Tv® cashier's checVs dra vnona
ono In the amount of $29,&03»10
and the second for $1,163,12. I
2. The chads should bo forwarded to Chief, TSS/Chealcal
Division, through TSS/kudget Officer, no. later than >0 September
1955.
3. The tvo Invoices covering this subproject aggregate
{45. 555.22. and ado use of tho balance of the Tl 55 funds,
plus the Ff 56 funds obligated tomato under this subpr oject . ■
Since it is expected that additional ft 56 funds vill be t
obligated under this subproject, the fil es on this project
should not be closed, .
~Y 1 r,.- 1
ri’hDS AKE
AVAILABLE:
" ^ jpjt# 2 ' ■- -!? < 3 * /
Vlfif
< * ■ ■ ’ « _ . . » vj sj r * i v - ^
Attachments 1 ^
Invoice & Certifications
Distribution*
Orlg & 2 - Addresses
1 - Coaptrollar
SIDK1.T CWTLI13
Chief
TsVCbe^ 10 * 11 W vision
CHEGKm^£*^.'.\i THE AMOUNT DF
FEwEivnr*. hozi
»:;s
s»/r
C H E C I U THE AM C
TSS/CD ^ (13 September 1955)* E C EIVt5 ’*
•i? - lo
Baccy University
? Grant
Director I Dr. Carl C. Ffe lifer
Be port of Receipts and Expenditures for the Period
June 1, 195 5 * ' Va? 31 y 1955
Receipt#,
^,035.00
Direct Expenditures i»
Fersonnel
Travel
Equipocot
Expendable Supplies
Total Direct Expenditure#
Contribution to Indirect Cost
(10# of Direct Expenditures)
Total Expenditure#
Unexpended Balance Hxy 31/ 1955
*See attached schedule# — -
$n,392.3§
3Q?*56
8,971*21
~l.cg9. 73
$?1,702.86
23 . 873.15
Approved!
.-/>/ s.QS/j'u
£;ory University
Vfc Jew:
3. s-ufc
f
3
Eaory University
Grant
June 1,' 1954
m 31> 1955
FTOSCKIOT,
Positioa
Student As s is teat
Instructor
Assistant Professor
Student Assistant
Social Security
TOTAL
Aoount
$ 1*00.00
14 . 583.26
5.958.26
ato.oo
Pio .84
$ n. 392 .B 6
;
c
' iT'-^O
E&ory University
June l, 1954 - my 31# 1955
lie*
EQurpt^jyr
Amount
Electrical Material#
Wardrobe cabinet*
Wall case*
Desk
FJle cabinets
Buriier tips, glass blcver
Freight
Furae hood and Distillation hood
Chairs ani tray# .
Mmroemtic Calculator
Balance
Type writer
Burner tips
Labolux Microscope r
Vesta basket#
Dizor lacps •
Class Hover eloper
Flashlight
Da tor lamp#
Screvplates, vrenches, pliers, drill#
Supports, large
Gas rachine, tegs, headetrap#
Regulating transforoer
French
Reducing Adapter
Baser L&np
Pipe lines for air ccapressor
Support, L&rge
Stopwatch holder# - : ~
Tiier#
Pusp, Centrifugal
(Credit on adapter
Clasps ar»l caster# ~
Foea rubber va tires#
2 Puaps, centrifugal
Tjcos blood pressure outfits ^
G. K. fans and clock#
O/ca, centrifuge
Generators, pever supply, preamplifiers
$ 16.9$
171.50
306.SA
125.27
127.08
7-99
2,22
1,322.59
279-9*
65*. 85
39-90
190.75
2.53
641.18
3.9*
93.73
2.5$
3.89
32.93
90.27
13.39
220.32
30.90
2.82
5.30
16.45
216.84
2.68
8.14
23.05
42.75
( •<*)
16.49
34.93
85.49
78.23
84.57
1,021,25
1. 106.37
7.197 .0$
Pags 2#
Ealaoco Brought PorvaxA. *.
Shelves
Bitrcvaf e Kit —
Spi-^o Inara Hoaoters
4 Vfceel cylinder truck
pliers, vrencbea
Steel cabinets
Steel cabinets
A’lioptieal preforcer $00 projecter, case & screen .
Velck pucp, Hydrogenati on apparatus, stirring apparatus
Receptacle
Vacuua tygon tubing .
Shelve e
Chairs
Jactson Supports ----- :
$ 7 , 197*09
70.00
322.56
154.44
154 .Mi
4l,£0
40.30
132 .5 7
122.84
615.43
6.44
39,66
10.00
12/. 99
_J 3 i 32
Total
r
‘TO
psiory University
f&nt
tm> 1, 195>* - M 1 / 31. W55
TOfPKNIABL'8 gJPH.ISS
Itea
Cheaicads
Chemical*
CV.eclcal 8
pipe, connection*
Freight
Cte.vice.ls
pressure transducer j —
12 6iAll clasps
8 Hargrove clanp#
Clerical* .
LiQuld resin Adhesive
Long distance telephone - m =
Chemicals
•Tubes, batteries, gauge ,
tr.y. ytmty co aUlrer.
Long distance telephone
Long distance telephone
Babbits „
Advertising in "Science
Long distance tele phone , . RkcA d,
Booh - "AntineUbolites & Cancer **
Cbenieals, gla&svir#, syringes
Photographic Vorfc
gcapel blades I cotton sionges
Chen leal s
Kymograph Paj«r
Boohs, Reference
Chcciicals
Batteries
p.:ry piper# tubing
Cylinders
Arount
Total
CONFIDENTIAL
UNCLASSIFV
C' x
"-' 17-11
8 August 1955
KS-S3UKD0M FOil CCKPfttOUAB
Atmnoi « Fimiioo Division
503 JiCl i • KCUUBAj Subprojoot 47, Addition®!
>Autboriiatio» So, £/
\ • '
\
t .. .
Ifedor tio authority granted In th® rsoaorandoa da tod
13 April 1953, froa tha PCI to^tba tt>/A and Uo extorvsion
of this authority In tfabreqnsot eerorand®, ^bprojoct 47
V 33 previously apprevod, CMer th® &xm authority an
eddltloa&l gua of $30,555.23 haa Uon author! tod to covor
tho ©jbproJoQt's erpenaas (thereby bringing to a total of
$30,555.33 fusds obligated during FI 5*5) to to charged to ._.-
Allotment 6-2502-10-001,
sidkh oorruia
Chisf :
S$§/OxxdcsX Pi virion
i
!
i
I
i
i
i
afh<c r/ii> ?ca
0-3I.IGAT 103 C? FU^Sl
■ Ee&o&reh Director
l}&
tS&s
Data*
K
\
lstributloQl
Qrlg 6 2- A ddreseo*
' 1 - TSS/OC
\ll - TSS/?> S3
1 - TSS/SIB
^ 2 - TSS/CD
YfiP.I^9» Pj
I
fc.
I
is
I
l
i
t
1
i
!
I
i
i
i
i
i
i
j
?
«
I
i
i
i
•*T*T*’
MEMQFEAMLiUM FOR; mB RECORD
SUBJECT: Addendum to Subproject 47
c
28 July 1955
7 ?- 7A.
• *
1. The purpose of this addendum is to set forth the mutual
administrative responsibilities of the contractor and sponsor*
2. The above subproject represent the research program of
Dr. Carl Pfeiffer located at Emory University covering the period
of 1 July 1955 through 30 June 1956.
3- The principal In vest igator shall submit to the sponsor,
at six month intervals, an informal statement of expenditures of
monies advanced for research activities. It is requested that
the statement be submitted in essentially the following fora:
a. Personal Compensation (Salaries, Subject Fees),
b. Equip ment ,
c. Suppli e s and Services,
d. Travel,
e . Overhead,
f. Contingencies •
Also, requested Emory University to submit
to them a surer-ary' accounting of monies received from the Fund. They
also requested the return of any unex pended funds received under
a grant from the Fund. L
h. Title to any p ermanent equipment jau chased by funds
granted the University shall be retained by the University in
lieu of higher overhead rates. ‘
5* It vas mutually- agreed -that documentation and accounting
for travel expenses which are reimbursable by the University
shall conform with the accepted practices of that Institution.
6. It vas agreed that technical reports reflecting the
progress of the research program shall be submitted at mutually
acceptable intervals.
Chief
TSS/Cbemical Division
Date
(Signature)
/ftf
m
■a
.. .
:-* J
•
-:*■
MEMORANDUM .RECEIPT
io:
from:
SUBJECT:
cm
I hereby acknowledge receipt of the following:
CMI-ICK^^/lN the: AMOUNT UF &£&{*'■
RECEIVED.
.* f* * « ># V /'✓ ✓ ✓ Oi> .
rt* mi ritum.
U m . ..T - no,
u« *• ••
.•Igattf e«p/{U>) ef iMt 'rtetfpl
nr ftECtMcnl
Ami t a ms
HU «(UKU
• « # • *rrr/
^ HEHORAKDUHL RECEIPT
FROM:
SUBJECT:
I hereby acknowledge receipt of. the following:
CHECK#Z&#|N THE amount' DR bj/jbZ
RECEIVED. ^
H»«%» rit«n
T» - '
,e, < »®*
Ml* III!
/
, tlgitiJ ttrjrllul 6f .IM* r*c*1(t
uuimm
6»H
(^^\ ~
" * X
f I '
•r
v? -tt
1 April 19ft
KSKRArnHw irar-can/,' ftkancs wnsioi .
vi i ■ ■’ .-- t iss/p^t officer - .-; > ~ryi- •■-- •;■
1.1
$U3J£Cf
t Project KOTLEU, Sdbproject So. 47,
InSlco /l, J^yS-lO-on.
%
• «. < ** ■ _•* . i- **.-
IsYolee Ho. 1 for Sdbprojec t 47 of Project JSHJWfA 1«
attached. Other invoices vlU follow laUr. It i« re-
pasted that p^aoat be mM hr tvo cashiers excels, one
Jaj the amount of$U,OCO.OO, aixl ore for
Chocls cLild ho sent to Chief, KS/CD through KS/^et
Officer ly Vod-neala/, 4 April 1955,
51PH1I OOTTLIFB
Chief
AVtacbaeatsl .
Inroioa & fortific atio ns
DiatrlUitioni
Grig & Z - Addressee
, \ Controller
**“ \ji - tss/fasb
2 - TSS/CD
* WIX94
lSS/Cb«aIcal Division
CHECK #ua&. IN THE AMOUNT OE $tp
*£ C£ '?Z 2 J?$J 3 J2S«v*^ 4
Ste
t CERTIFY THAT FUNDS ARE AVAILABLE;
aPT ..
oiUG.vnot: Rf.rrr-^N-E No- - — — - •--- *
-r- z>3**~ ' c
CSASC-. TO •LLO-n’XGT No - -»* • ~
4 APR ENT0_
" ^UTlT6RlziN^FnC ER
?HECK&^//|N THE AMOUNT DE $f£^
RECEIVED.
-secret
INVOICS NO. 1 ;
- ' ' $\ IferA 1955
ra m? I CATIONS
(l) It Is hereby certified th.it this is lnvolco Ko. 1 WVJjJ
to Subproject 47 of reject KKUL1SA, that performance vaa satis-
factory, that the sex-rices vero accomplished In accordance vlth
mt^^roe^nts, that a detaUM agenda of the payouts and - .
on file in TSS/CD, that this bill Is Just and cor-
red Lid that paynant thereof has not yet been »**e.
Patel
SIDttPf GOTTLIEB
Chief, TSS/CD
(2) It Is hereby certified . that this Invoice applies to Sub-
projoct 47 unde/ Project KKOURA vhich vas duly approyed and
that the project is boil* carried out in accordance vlth the
B^iaorendem dated 13 April 1953 froa the Pci to the PD/JL, and
Aha extension of this authority In subsequent s^eocrendA.
Da tel
f?tr
J&UL44J
- r -t'
March 1955
Cjj. -1&
^KPJLiS>OH FC£» CffiFff.OU® /•• •
jLirbrricai' * pwl P l011 •>•••'/ \b : ■
a^fflCtN'. . rwJcil«U«M. .^rojcoU? . ' ■
fctoi*. .JUy ««»** u ** * 89 " a4 “ W
lyrll 195 } ft® W A« «M «* « U « sl “ ef 1
til. *iU»rU 7 ^ «***»“* M “ r031 ’' ” *"
W W ^, ^ <>5.«O.CO ofU, — U *°J«‘ "
^ a.. 1~» cM. e »tM to ««* W. •*—«.
( .>1 ,v*ja t*> tJtfrzod t« lUoUont 5 -2593-JO 201.
tswciij) tcr oduoatios
Cf TCfSPSi : _
SSp^
sicks! corrUfS- '
Chiof
ISS/Clicaiwi Divide*
y^v^i^ieftreH Director
^ J»An 2 -i 1=55 ZZ
Palo i . . Z— — — —
Pietrilotl «»* .
OrlS i> t m tiS/M***
><L - tss/fasb
1 - TS s/£RB
2 - ISS/O -
....
i CLFTlf l Tnr.Vi
C*Ur/.TiOS -••'-i i: -
C: 1 -*-.:- g; to ,\uct.-:::M » ; s _
Z i.vAn.r.r'tE:
_ /// _ ...,
S'
— nr atfrt" 73
1
Of.-’iCEK
4
,4V» a
Do-rr.gr.Ylcd to* COSffflHittl /
by a utuopfly of: jmvii
<!ale: Jiwe IST?' //
E2 l)Z%Zp$L BY 187475
SCOPE OF PRQJSffiL
/ ■ i
You will find enclosed a proposed budget for 1955-56
beginning with July ir 1955. With this proposed budget, we
would be able to do all of the pharmacological; testing re-
quired by testing of
new compounds iraBrSt this Unive rsity jmd o ther c ompounds^ ^
which would be submitted by you/'^^^^and
This would also include screening compounds of medic ina l
origin supplied by the Australian scientists and by Ip*""-.
WhW^the'^haraacologlcal^techhicien'vas not busy we_-
would plan to have her continue a careful study in mice and
rats of CNS stimulants which might antidote the acute effects
of alcohol.
The travel budget may appear rather large but this is
nece^ in o rder to ., c^iruJO our testing program in man at
Doy/ngr a d e^/Vot pMTIJl
by cuthpiuty <£?fl37475~
dete:/fune
:.; j £2 mPDj^s CL BY 187475
23 March 1955
W.7
MEMORANDUM FOR: THE RECORD
SUBJECT
: Project KKULTRA, Subproject 4?
1. This purpose of this project is to provide funds for the
study of drugs affecting the central nervous system, and to screen
and evaluate pharmacologically an y other com pounds which may be
of interest to J'SS/Chemical Division. ;
2. The attached proposal indicates the extent of the investi-
gations that will be carried out in these facilities available at
Emory University and provides for close cooperation with the work
j ^twmbo transferred using the
usual manner. ^ '
4. The cost of this program for a period of one year begin-
ning 1 July 1955 will be $ 43.803. 1 0 to which must be added four •
percent m fee to making the total amount
$45,555.22. At the present time $15,000.00 is being committed,
$14,400 for the project and $600.00 fee to the r>
The balance of the total will be committed at a later date,
5. Both ■ and Dr. # Pfeiffer are cleared TOP
SECRET by the Agency and are avare of the sensitive nature of
this work,
APPROVED FOR OBLIGATION
OF. FUNDS:
I rT
Research Director
MM
TSS/Chemcal Division
APPROVED*
Date: A ** *
Attachment:
Proposal . /f • - j"
totnzraiA toyXC«fik.'f[!
Original Only t/ culprit y Atl l/ih7$
dote: /une J977 / / /
AP, PROVED FOR ADDITIONAL
•PisoTOT/'rrruj ns* /'nfi
.^jS^^^APIROraTATJON OF $30,555.22:
lesearch Director
12 I't'-Pr/; CL/M 1?
AUG 9 ?3SS
Date!
fcy • fxniyCr lty Jw'* 18H75
date:/june *977
E2 I&Et;
•'5 / ., v 1 UJ9-
Ph.D^ M.D., Principal Investor
Salaries:
1 Research Tech.
2 Grad. Students
Resear ch Tech.
§7,000 + 2*, + #
3,600 «
h,800 ..».
C- 3,000 *
2,lj00 **
1 Grad. Student 2,U00
Consultant . , riA
(Carl C. Pfeiffer) 2,h00 --
Part-time secretary _ UOQ *
* nSMl 5 °* gs^fcs
2 % OASB /
<i Retirement) . 2^121.00
§32,1:21.00
§30,3CO.OO
Consumable Supplies & equipment §6,000
Travel
1 , 1:00
§? 7Goo
10JS Universi-
ty Overhead
7 , 1 ) 00.00
§ 397521*00
3.982.10
* At present paid from departmental fund*
t
#
# At present paid from departmental funds
v-a- New items
*£
'IT* '“
^U'^/^-S'jSrAwi’.-^atiaK til
M liVlVET | CL BY 187475
^t^Moror University
Emory University. Georgia
. Q C y**-tr 4-7
h ? - n
Division of Basic Sciences March I}, i9$$
In the Health Services
Department of Fharmcology
Dr. Sidney Gottlieb
S ^ nt ^ ic $&g££?tg&ZL
Dear Dr. Gottlieb: ^
Enclosed yon will find two copies of our report on the^^^^^compound vhich
includes a request for more of Compound No. _. fEB._li-99II._- We are sending this report
at this time so that you can have more of this compound made to continue our pharma-
cological testing. B?
^ In addition, you will" find enclosed a prop osed budg et f/r 195£-56 beginning^
vith July 1, 1955. With this proposed budget, ve would be, able to do all of the
pharmacological testing required tor • t he Y including the testing of
new comoounds made at this UiTivers^v^nd other compounds which would be submitted
C,by vou Thls^vould also include screening com-
■ aim. __ -
pounds of medicinal origin supplied by the scientists and
Vhen the pharmacological tectiniciah was hot busy we would plan to have her continue
a careful study in mice and rats of CNS stimulants which might antidote the acute
effects of^lcohcl.
i
You will note that we also have attached a bare minimum budget which would pro-
vide for the expenditures now made by the department f or Bln
order to get the laboratory work started we have had engaged C—
full-time at departmental expense on r obi e ms as well as a secretary
part-time and an animal man half-time. If the full expanded program is not read ir ed
try the then ve would drop back to the bare minimum budget as out-
lined on the attached sheet.
ft
Durir.-gSgg^tg* visit we outlined our progress in several portio ns of °} } r_re -
search program and if a formal report is required immediately by the*>^^^^^©l** To
this can be provided. We will of course have a detailed report at the end of
Juno covering progress during the first year of support, of this research program.
£
✓Trie travel budget may appear rather laAe but this i s n ecessar y in order to
continue our testing program in man at [2,
Yours sincerely.
•C/y
Carl C. ^Pfeiffer, K.D.
D r/OIqjS C&BJft I-IST
JKII/IRA Subproject * .
At - ' ‘ '
P3t3 of Original ?»ic4 ^Mise Extend Mlofent Aaounfc of
/tdditioo&l Period Titr-a Ex to;x3 ?d Allotticot Adouafe of
\ -5' < ?S6p-/ 0-Q Oj j X5~ COO.
Additional Period Tits* r~m „
; - S SS&--
— ~-— ■ 6^St^e:ead- 3a ssjj&S
Ji5 ' "i SsaeM
W^T ?~^ — — ~T— [— “f /S2.
«7^/%Vl '/') In Aqi« ,n, *S t }'*■•* j. x ' '* fA
<t? lljttork >10. La.t’1 , L 5~0 S^ocfl
XVI '%*-■ %^fi
M l^ ,no X
ii tvi-ut cvf
CMifotioa
T^lr.n^-y-
— L^sxe^
— — f - — L
L±i j $.330.01, . „ !
.■-.i~..l.lhku....\ /ijv.ot .jx.Uk.nt.
~j> jMkj>± -l-ZpC&tii. ' <r
— L.SO** ■^ r M. > U£.^ZM^2LjA.
— J — mem.Li % I isjirwo - 4 -,; • ►
— 7 — l^m
&tijj>._._ /^LLl— " \..<52>.a' o.*f _
._JL_ \j£f ££4 0/ '■
. h*u\ . - ■ , - ; j
1 _ „%^df . T ^Rper?^ssiT^4 3 / a /a •
=£*&¥*- s^V/y. 9 a.
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